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Beneficial Effects of Soluble Guanylyl Cyclase Stimulation and Activation in Sickle Cell Disease Are Amplified by Hydroxyurea: In Vitro and In Vivo Studies.
Ferreira WA Jr, Chweih H, Lanaro C, Almeida CB, Brito PL, Gotardo EMF, Torres L, Miguel LI, Franco-Penteado CF, Leonardo FC, Garcia F, Saad STO, Frenette PS, Brockschnieder D, Costa FF, Stasch JP, Sandner P, Conran N. Ferreira WA Jr, et al. Among authors: brito pl. J Pharmacol Exp Ther. 2020 Sep;374(3):469-478. doi: 10.1124/jpet.119.264606. Epub 2020 Jul 6. J Pharmacol Exp Ther. 2020. PMID: 32631869 Free PMC article.
Reduced blood pressure in sickle cell disease is associated with decreased angiotensin converting enzyme (ACE) activity and is not modulated by ACE inhibition.
Brito PL, Dos Santos AF, Chweih H, Favero ME, Gotardo EMF, Silva JAF, Leonardo FC, Franco-Penteado CF, de Oliveira MG, Ferreira WA Jr, Zaidan BC, Billis A, Baldanzi G, Mashima DA, Antunes E, Saad STO, Costa FF, Conran N. Brito PL, et al. PLoS One. 2022 Feb 3;17(2):e0263424. doi: 10.1371/journal.pone.0263424. eCollection 2022. PLoS One. 2022. PMID: 35113975 Free PMC article.
Piezo1 activation augments sickling propensity and the adhesive properties of sickle red blood cells in a calcium-dependent manner.
Nader E, Conran N, Leonardo FC, Hatem A, Boisson C, Carin R, Renoux C, Costa FF, Joly P, Brito PL, Esperti S, Bernard J, Gauthier A, Poutrel S, Bertrand Y, Garcia C, Saad STO, Egée S, Connes P. Nader E, et al. Among authors: brito pl. Br J Haematol. 2023 Aug;202(3):657-668. doi: 10.1111/bjh.18799. Epub 2023 Apr 3. Br J Haematol. 2023. PMID: 37011913
Abstracts from the 8th International Conference on cGMP Generators, Effectors and Therapeutic Implications : Bamberg, Germany. 23-25 June, 2017.
Todd Milne G; on behalf of the Ironwood team; Sandner P, Lincoln KA, Harrison PC, Chen H, Wang H, Clifford H, Qian HS, Wong D, Sarko C, Fryer R, Richman J, Reinhart GA, Boustany CM, Pullen SS, Andresen H, Moltzau LR, Cataliotti A, Levy FO, Lukowski R, Frankenreiter S, Friebe A, Calamaras T, Baumgartner R, McLaughlin A, Aronovitz M, Baur W, Wang GR, Kapur N, Karas R, Blanton R, Hell S, Waldman SA, Lin JE, Colon-Gonzalez F, Kim GW, Blomain ES, Merlino D, Snook A, Erdmann J, Wobst J, Kessler T, Schunkert H, Walter U, Pagel O, Walter E, Gambaryan S, Smolenski A, Jurk K, Zahedi R, Klinger JR, Benza RL, Corris PA, Langleben D, Naeije R, Simonneau G, Meier C, Colorado P, Chang MK, Busse D, Hoeper MM, Masferrer JL, Jacobson S, Liu G, Sarno R, Bernier S, Zhang P, Todd Milne G, Flores-Costa R, Currie M, Hall K, Möhrle D, Reimann K, Wolter S, Wolters M, Mergia E, Eichert N, Geisler HS, Ruth P, Friebe A, Feil R, Zimmermann U, Koesling D, Knipper M, Rüttiger L, Tanaka Y, Okamoto A, Nojiri T, Kumazoe M, Tokudome T, Miura K, Hino J, Hosoda H, Miyazato M, Kangawa K, Kapil V, Ahluwalia A, Paolocci N, Eaton P, Campbell JC, Henning P, Franz E, Sankaran B, Herberg FW, Kim C, Wittwer M, Luo Q, Kaila V… See abstract for full author list ➔ Todd Milne G, et al. Among authors: brito pl. BMC Pharmacol Toxicol. 2017 Oct 10;18(Suppl 1):64. doi: 10.1186/s40360-017-0170-5. BMC Pharmacol Toxicol. 2017. PMID: 29035170 Free PMC article. No abstract available.
Gastric hemangioma in a 5-year-old boy.
Schettini ST, Ribeiro RC, Brito PL, Abib Sde C, Onofre LS, Kawasaki LH, Seda Neto J. Schettini ST, et al. Among authors: brito pl. J Pediatr Surg. 2007 Apr;42(4):717-8. doi: 10.1016/j.jpedsurg.2006.12.044. J Pediatr Surg. 2007. PMID: 17448773
15 results