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Plasma-Derived Hemopexin as a Candidate Therapeutic Agent for Acute Vaso-Occlusion in Sickle Cell Disease: Preclinical Evidence.
Gentinetta T, Belcher JD, Brügger-Verdon V, Adam J, Ruthsatz T, Bain J, Schu D, Ventrici L, Edler M, Lioe H, Patel K, Chen C, Nguyen J, Abdulla F, Zhang P, Wassmer A, Jain M, Mischnik M, Pelzing M, Martin K, Davis R, Didichenko S, Schaub A, Brinkman N, Herzog E, Zürcher A, Vercellotti GM, Kato GJ, Höbarth G. Gentinetta T, et al. Among authors: brinkman n. J Clin Med. 2022 Jan 26;11(3):630. doi: 10.3390/jcm11030630. J Clin Med. 2022. PMID: 35160081 Free PMC article.
Haptoglobin and hemopexin inhibit vaso-occlusion and inflammation in murine sickle cell disease: Role of heme oxygenase-1 induction.
Belcher JD, Chen C, Nguyen J, Abdulla F, Zhang P, Nguyen H, Nguyen P, Killeen T, Miescher SM, Brinkman N, Nath KA, Steer CJ, Vercellotti GM. Belcher JD, et al. Among authors: brinkman n. PLoS One. 2018 Apr 25;13(4):e0196455. doi: 10.1371/journal.pone.0196455. eCollection 2018. PLoS One. 2018. PMID: 29694434 Free PMC article.
Intravascular hemolysis activates complement via cell-free heme and heme-loaded microvesicles.
Merle NS, Grunenwald A, Rajaratnam H, Gnemmi V, Frimat M, Figueres ML, Knockaert S, Bouzekri S, Charue D, Noe R, Robe-Rybkine T, Le-Hoang M, Brinkman N, Gentinetta T, Edler M, Petrillo S, Tolosano E, Miescher S, Le Jeune S, Houillier P, Chauvet S, Rabant M, Dimitrov JD, Fremeaux-Bacchi V, Blanc-Brude OP, Roumenina LT. Merle NS, et al. Among authors: brinkman n. JCI Insight. 2018 Jun 21;3(12):e96910. doi: 10.1172/jci.insight.96910. eCollection 2018 Jun 21. JCI Insight. 2018. PMID: 29925688 Free PMC article.
Characterization of Renal Injury and Inflammation in an Experimental Model of Intravascular Hemolysis.
Merle NS, Grunenwald A, Figueres ML, Chauvet S, Daugan M, Knockaert S, Robe-Rybkine T, Noe R, May O, Frimat M, Brinkman N, Gentinetta T, Miescher S, Houillier P, Legros V, Gonnet F, Blanc-Brude OP, Rabant M, Daniel R, Dimitrov JD, Roumenina LT. Merle NS, et al. Among authors: brinkman n. Front Immunol. 2018 Mar 1;9:179. doi: 10.3389/fimmu.2018.00179. eCollection 2018. Front Immunol. 2018. PMID: 29545789 Free PMC article.
Pleckstrin-2 is essential for erythropoiesis in β-thalassemic mice, reducing apoptosis and enhancing enucleation.
Feola M, Zamperone A, Moskop D, Chen H, Casu C, Lama D, Di Martino J, Djedaini M, Papa L, Martinez MR, Choesang T, Bravo-Cordero JJ, MacKay M, Zumbo P, Brinkman N, Abrams CS, Rivella S, Hattangadi S, Mason CE, Hoffman R, Ji P, Follenzi A, Ginzburg YZ. Feola M, et al. Among authors: brinkman n. Commun Biol. 2021 May 3;4(1):517. doi: 10.1038/s42003-021-02046-9. Commun Biol. 2021. PMID: 33941818 Free PMC article.
86 results