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GDF8 inhibition enhances musculoskeletal recovery and mitigates posttraumatic osteoarthritis following joint injury.
Brightwell CR, Latham CM, Keeble AR, Thomas NT, Owen AM, Reeves KA, Long DE, Patrick M, Gonzalez-Velez S, Abed V, Annamalai RT, Jacobs C, Conley CE, Hawk GS, Stone AV, Fry JL, Thompson KL, Johnson DL, Noehren B, Fry CS. Brightwell CR, et al. Sci Adv. 2023 Dec;9(48):eadi9134. doi: 10.1126/sciadv.adi9134. Epub 2023 Nov 29. Sci Adv. 2023. PMID: 38019905 Free PMC article.
Small molecule nicotinamide N-methyltransferase inhibitor activates senescent muscle stem cells and improves regenerative capacity of aged skeletal muscle.
Neelakantan H, Brightwell CR, Graber TG, Maroto R, Wang HL, McHardy SF, Papaconstantinou J, Fry CS, Watowich SJ. Neelakantan H, et al. Among authors: brightwell cr. Biochem Pharmacol. 2019 May;163:481-492. doi: 10.1016/j.bcp.2019.02.008. Epub 2019 Feb 10. Biochem Pharmacol. 2019. PMID: 30753815 Free PMC article.
Thermal injury initiates pervasive fibrogenesis in skeletal muscle.
Brightwell CR, Hanson ME, El Ayadi A, Prasai A, Wang Y, Finnerty CC, Fry CS. Brightwell CR, et al. Am J Physiol Cell Physiol. 2020 Aug 1;319(2):C277-C287. doi: 10.1152/ajpcell.00337.2019. Epub 2020 May 20. Am J Physiol Cell Physiol. 2020. PMID: 32432932 Free PMC article.
32 results