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The Mithralog EC-7072 Induces Chronic Lymphocytic Leukemia Cell Death by Targeting Tonic B-Cell Receptor Signaling.
Lorenzo-Herrero S, Sordo-Bahamonde C, Bretones G, Payer ÁR, González-Rodríguez AP, González-García E, Pérez-Escuredo J, Villa-Álvarez M, Núñez LE, Morís F, Gonzalez S, López-Soto A. Lorenzo-Herrero S, et al. Among authors: bretones g. Front Immunol. 2019 Oct 18;10:2455. doi: 10.3389/fimmu.2019.02455. eCollection 2019. Front Immunol. 2019. PMID: 31681329 Free PMC article.
Altered patterns of global protein synthesis and translational fidelity in RPS15-mutated chronic lymphocytic leukemia.
Bretones G, Álvarez MG, Arango JR, Rodríguez D, Nadeu F, Prado MA, Valdés-Mas R, Puente DA, Paulo JA, Delgado J, Villamor N, López-Guillermo A, Finley DJ, Gygi SP, Campo E, Quesada V, López-Otín C. Bretones G, et al. Blood. 2018 Nov 29;132(22):2375-2388. doi: 10.1182/blood-2017-09-804401. Epub 2018 Sep 4. Blood. 2018. PMID: 30181176 Free PMC article.
Autophagy-linked plasma and lysosomal membrane protein PLAC8 is a key host factor for SARS-CoV-2 entry into human cells.
Ugalde AP, Bretones G, Rodríguez D, Quesada V, Llorente F, Fernández-Delgado R, Jiménez-Clavero MÁ, Vázquez J, Calvo E, Tamargo-Gómez I, Mariño G, Roiz-Valle D, Maeso D, Araujo-Voces M, Español Y, Barceló C, Freije JM, López-Soto A, López-Otín C. Ugalde AP, et al. Among authors: bretones g. EMBO J. 2022 Nov 2;41(21):e110727. doi: 10.15252/embj.2022110727. Epub 2022 Oct 4. EMBO J. 2022. PMID: 36124427 Free PMC article.
High p27 protein levels in chronic lymphocytic leukemia are associated to low Myc and Skp2 expression, confer resistance to apoptosis and antagonize Myc effects on cell cycle.
Caraballo JM, Acosta JC, Cortés MA, Albajar M, Gómez-Casares MT, Batlle-López A, Cuadrado MA, Onaindia A, Bretones G, Llorca J, Piris MA, Colomer D, León J. Caraballo JM, et al. Among authors: bretones g. Oncotarget. 2014 Jul 15;5(13):4694-708. doi: 10.18632/oncotarget.2100. Oncotarget. 2014. PMID: 25051361 Free PMC article.
Molecular pathogenesis of CLL and its evolution.
Rodríguez D, Bretones G, Arango JR, Valdespino V, Campo E, Quesada V, López-Otín C. Rodríguez D, et al. Among authors: bretones g. Int J Hematol. 2015 Mar;101(3):219-28. doi: 10.1007/s12185-015-1733-0. Epub 2015 Jan 29. Int J Hematol. 2015. PMID: 25630433 Free article. Review.
MYC antagonizes the differentiation induced by imatinib in chronic myeloid leukemia cells through downregulation of p27(KIP1.).
Gómez-Casares MT, García-Alegria E, López-Jorge CE, Ferrándiz N, Blanco R, Alvarez S, Vaqué JP, Bretones G, Caraballo JM, Sánchez-Bailón P, Delgado MD, Martín-Perez J, Cigudosa JC, León J. Gómez-Casares MT, et al. Among authors: bretones g. Oncogene. 2013 Apr 25;32(17):2239-46. doi: 10.1038/onc.2012.246. Epub 2012 Jun 18. Oncogene. 2013. PMID: 22710719
Myc and cell cycle control.
Bretones G, Delgado MD, León J. Bretones G, et al. Biochim Biophys Acta. 2015 May;1849(5):506-16. doi: 10.1016/j.bbagrm.2014.03.013. Epub 2014 Apr 1. Biochim Biophys Acta. 2015. PMID: 24704206 Free article. Review.
p21 as a transcriptional co-repressor of S-phase and mitotic control genes.
Ferrándiz N, Caraballo JM, García-Gutierrez L, Devgan V, Rodriguez-Paredes M, Lafita MC, Bretones G, Quintanilla A, Muñoz-Alonso MJ, Blanco R, Reyes JC, Agell N, Delgado MD, Dotto GP, León J. Ferrándiz N, et al. Among authors: bretones g. PLoS One. 2012;7(5):e37759. doi: 10.1371/journal.pone.0037759. Epub 2012 May 25. PLoS One. 2012. PMID: 22662213 Free PMC article.
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