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Optogenetic therapy: high spatiotemporal resolution and pattern discrimination compatible with vision restoration in non-human primates.
Gauvain G, Akolkar H, Chaffiol A, Arcizet F, Khoei MA, Desrosiers M, Jaillard C, Caplette R, Marre O, Bertin S, Fovet CM, Demilly J, Forster V, Brazhnikova E, Hantraye P, Pouget P, Douar A, Pruneau D, Chavas J, Sahel JA, Dalkara D, Duebel J, Benosman R, Picaud S. Gauvain G, et al. Among authors: brazhnikova e. Commun Biol. 2021 Jan 27;4(1):125. doi: 10.1038/s42003-020-01594-w. Commun Biol. 2021. PMID: 33504896 Free PMC article.
A New Promoter Allows Optogenetic Vision Restoration with Enhanced Sensitivity in Macaque Retina.
Chaffiol A, Caplette R, Jaillard C, Brazhnikova E, Desrosiers M, Dubus E, Duhamel L, Macé E, Marre O, Benoit P, Hantraye P, Bemelmans AP, Bamberg E, Duebel J, Sahel JA, Picaud S, Dalkara D. Chaffiol A, et al. Among authors: brazhnikova e. Mol Ther. 2017 Nov 1;25(11):2546-2560. doi: 10.1016/j.ymthe.2017.07.011. Epub 2017 Jul 20. Mol Ther. 2017. PMID: 28807567 Free PMC article.
Noninvasive gene delivery to foveal cones for vision restoration.
Khabou H, Garita-Hernandez M, Chaffiol A, Reichman S, Jaillard C, Brazhnikova E, Bertin S, Forster V, Desrosiers M, Winckler C, Goureau O, Picaud S, Duebel J, Sahel JA, Dalkara D. Khabou H, et al. Among authors: brazhnikova e. JCI Insight. 2018 Jan 25;3(2):e96029. doi: 10.1172/jci.insight.96029. eCollection 2018 Jan 25. JCI Insight. 2018. PMID: 29367457 Free PMC article.
Clinical-grade production and safe delivery of human ESC derived RPE sheets in primates and rodents.
Ben M'Barek K, Bertin S, Brazhnikova E, Jaillard C, Habeler W, Plancheron A, Fovet CM, Demilly J, Jarraya M, Bejanariu A, Sahel JA, Peschanski M, Goureau O, Monville C. Ben M'Barek K, et al. Among authors: brazhnikova e. Biomaterials. 2020 Feb;230:119603. doi: 10.1016/j.biomaterials.2019.119603. Epub 2019 Nov 6. Biomaterials. 2020. PMID: 31732225 Free article.
Behavioural responses to a photovoltaic subretinal prosthesis implanted in non-human primates.
Prévot PH, Gehere K, Arcizet F, Akolkar H, Khoei MA, Blaize K, Oubari O, Daye P, Lanoë M, Valet M, Dalouz S, Langlois P, Esposito E, Forster V, Dubus E, Wattiez N, Brazhnikova E, Nouvel-Jaillard C, LeMer Y, Demilly J, Fovet CM, Hantraye P, Weissenburger M, Lorach H, Bouillet E, Deterre M, Hornig R, Buc G, Sahel JA, Chenegros G, Pouget P, Benosman R, Picaud S. Prévot PH, et al. Among authors: brazhnikova e. Nat Biomed Eng. 2020 Feb;4(2):172-180. doi: 10.1038/s41551-019-0484-2. Epub 2019 Dec 2. Nat Biomed Eng. 2020. PMID: 31792423 Free article.
Systemic administration of the di-apocarotenoid norbixin (BIO201) is neuroprotective, preserves photoreceptor function and inhibits A2E and lipofuscin accumulation in animal models of age-related macular degeneration and Stargardt disease.
Fontaine V, Monteiro E, Fournié M, Brazhnikova E, Boumedine T, Vidal C, Balducci C, Guibout L, Latil M, Dilda PJ, Veillet S, Sahel JA, Lafont R, Camelo S. Fontaine V, et al. Among authors: brazhnikova e. Aging (Albany NY). 2020 Apr 7;12(7):6151-6171. doi: 10.18632/aging.103014. Epub 2020 Apr 7. Aging (Albany NY). 2020. PMID: 32255762 Free PMC article.
AAV-Mediated Gene Delivery to Foveal Cones.
Bertin S, Brazhnikova E, Jaillard C, Sahel JA, Dalkara D. Bertin S, et al. Among authors: brazhnikova e. Methods Mol Biol. 2020;2173:101-112. doi: 10.1007/978-1-0716-0755-8_6. Methods Mol Biol. 2020. PMID: 32651912
In vivo optogenetic stimulation of the primate retina activates the visual cortex after long-term transduction.
Chaffiol A, Provansal M, Joffrois C, Blaize K, Labernede G, Goulet R, Burban E, Brazhnikova E, Duebel J, Pouget P, Sahel JA, Picaud S, Arcizet F, Gauvain G. Chaffiol A, et al. Among authors: brazhnikova e. Mol Ther Methods Clin Dev. 2021 Nov 22;24:1-10. doi: 10.1016/j.omtm.2021.11.009. eCollection 2022 Mar 10. Mol Ther Methods Clin Dev. 2021. PMID: 34977267 Free PMC article.
16 results