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Kinase-impaired BTK mutations are susceptible to clinical-stage BTK and IKZF1/3 degrader NX-2127.
Science. 2024 Feb 2;383(6682):eadi5798. doi: 10.1126/science.adi5798. Epub 2024 Feb 2.
Science. 2024.
PMID: 38301010
Discovery and Preclinical Pharmacology of NX-2127, an Orally Bioavailable Degrader of Bruton's Tyrosine Kinase with Immunomodulatory Activity for the Treatment of Patients with B Cell Malignancies.
Robbins DW, Noviski MA, Tan YS, Konst ZA, Kelly A, Auger P, Brathaban N, Cass R, Chan ML, Cherala G, Clifton MC, Gajewski S, Ingallinera TG, Karr D, Kato D, Ma J, McKinnell J, McIntosh J, Mihalic J, Murphy B, Panga JR, Peng G, Powers J, Perez L, Rountree R, Tenn-McClellan A, Sands AT, Weiss DR, Wu J, Ye J, Guiducci C, Hansen G, Cohen F.
Robbins DW, et al. Among authors: brathaban n.
J Med Chem. 2024 Feb 22;67(4):2321-2336. doi: 10.1021/acs.jmedchem.3c01007. Epub 2024 Feb 1.
J Med Chem. 2024.
PMID: 38300987
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Author Correction: Elevated complement mediator levels in endothelial-derived plasma exosomes implicate endothelial innate inflammation in diminished brain function of aging humans.
Elahi FM, Harvey D, Altendahl M, Brathaban N, Fernandes N, Casaletto KB, Staffaroni AM, Maillard P, Hinman JD, Miller BL, DeCarli C, Kramer JH, Goetzl EJ.
Elahi FM, et al. Among authors: brathaban n.
Sci Rep. 2022 Feb 1;12(1):2008. doi: 10.1038/s41598-022-05977-3.
Sci Rep. 2022.
PMID: 35105918
Free PMC article.
No abstract available.
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Elevated complement mediator levels in endothelial-derived plasma exosomes implicate endothelial innate inflammation in diminished brain function of aging humans.
Elahi FM, Harvey D, Altendahl M, Brathaban N, Fernandes N, Casaletto KB, Staffaroni AM, Maillard P, Hinman JD, Miller BL, DeCarli C, Kramer JH, Goetzl EJ.
Elahi FM, et al. Among authors: brathaban n.
Sci Rep. 2021 Aug 10;11(1):16198. doi: 10.1038/s41598-021-91759-2.
Sci Rep. 2021.
PMID: 34376699
Free PMC article.
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Lower White Matter Volume and Worse Executive Functioning Reflected in Higher Levels of Plasma GFAP among Older Adults with and Without Cognitive Impairment.
Asken BM, VandeVrede L, Rojas JC, Fonseca C, Staffaroni AM, Elahi FM, Lindbergh CA, Apple AC, You M, Weiner-Light S, Brathaban N, Fernandes N, Boxer AL, Miller BL, Rosen HJ, Kramer JH, Casaletto KB.
Asken BM, et al. Among authors: brathaban n.
J Int Neuropsychol Soc. 2022 Jul;28(6):588-599. doi: 10.1017/S1355617721000813. Epub 2021 Jun 22.
J Int Neuropsychol Soc. 2022.
PMID: 34158138
Free PMC article.
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Plasma Glial Fibrillary Acidic Protein Levels Differ Along the Spectra of Amyloid Burden and Clinical Disease Stage.
Asken BM, Elahi FM, La Joie R, Strom A, Staffaroni AM, Lindbergh CA, Apple AC, You M, Weiner-Light S, Brathaban N, Fernandes N, Karydas A, Wang P, Rojas JC, Boxer AL, Miller BL, Rabinovici GD, Kramer JH, Casaletto KB.
Asken BM, et al. Among authors: brathaban n.
J Alzheimers Dis. 2021;80(1):471-474. doi: 10.3233/JAD-219001.
J Alzheimers Dis. 2021.
PMID: 33612550
No abstract available.
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Plasma Glial Fibrillary Acidic Protein Levels Differ Along the Spectra of Amyloid Burden and Clinical Disease Stage.
Asken BM, Elahi FM, La Joie R, Strom A, Staffaroni AM, Lindbergh CA, Apple AC, You M, Weiner-Light S, Brathaban N, Fernandes N, Karydas A, Wang P, Rojas JC, Boxer AL, Miller BL, Rabinovici GD, Kramer JH, Casaletto KB.
Asken BM, et al. Among authors: brathaban n.
J Alzheimers Dis. 2020;78(1):265-276. doi: 10.3233/JAD-200755.
J Alzheimers Dis. 2020.
PMID: 32986672
Free PMC article.
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