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Pharmacokinetics and Pharmacodynamics of Key Components of a Standardized Centella asiatica Product in Cognitively Impaired Older Adults: A Phase 1, Double-Blind, Randomized Clinical Trial.
Wright KM, Bollen M, David J, Speers AB, Brandes MS, Gray NE, Alcázar Magaña A, McClure C, Stevens JF, Maier CS, Quinn JF, Soumyanath A. Wright KM, et al. Among authors: brandes ms. Antioxidants (Basel). 2022 Jan 23;11(2):215. doi: 10.3390/antiox11020215. Antioxidants (Basel). 2022. PMID: 35204098 Free PMC article.
Centella asiatica promotes antioxidant gene expression and mitochondrial oxidative respiration in experimental autoimmune encephalomyelitis.
Kundu P, Yasuhara K, Brandes MS, Zweig JA, Neff CJ, Holden S, Kessler K, Matsumoto S, Offner H, Waslo CS, Vandenbark A, Soumyanath A, Sherman LS, Raber J, Gray NE, Spain RI. Kundu P, et al. Among authors: brandes ms. Res Sq [Preprint]. 2023 Oct 6:rs.3.rs-3393042. doi: 10.21203/rs.3.rs-3393042/v1. Res Sq. 2023. PMID: 37886497 Free PMC article. Preprint.
Amelioration of age-related cognitive decline and anxiety in mice by Centella asiatica extract varies by sex, dose and mode of administration.
Gray NE, Hack W, Brandes MS, Zweig JA, Yang L, Marney L, Choi J, Magana AA, Cerruti N, McFerrin J, Koike S, Nguyen T, Raber J, Quinn JF, Maier CS, Soumyanath A. Gray NE, et al. Among authors: brandes ms. bioRxiv [Preprint]. 2024 Jan 24:2024.01.23.576700. doi: 10.1101/2024.01.23.576700. bioRxiv. 2024. PMID: 38328129 Free PMC article. Preprint.
Mode of administration influences plasma levels of active Centella asiatica compounds in 5xFAD mice while markers of neuroinflammation remain unaltered.
Speers AB, Wright KM, Brandes MS, Kedjejian N, Matthews DG, Caruso M, Harris CJ, Koike S, Nguyen T, Quinn JF, Soumyanath A, Gray NE. Speers AB, et al. Among authors: brandes ms. Front Neurosci. 2024 Mar 25;18:1277626. doi: 10.3389/fnins.2024.1277626. eCollection 2024. Front Neurosci. 2024. PMID: 38591068 Free PMC article.