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Systems biology analysis of the Clostridioides difficile core-genome contextualizes microenvironmental evolutionary pressures leading to genotypic and phenotypic divergence.
Norsigian CJ, Danhof HA, Brand CK, Oezguen N, Midani FS, Palsson BO, Savidge TC, Britton RA, Spinler JK, Monk JM. Norsigian CJ, et al. Among authors: brand ck. NPJ Syst Biol Appl. 2020 Oct 20;6(1):31. doi: 10.1038/s41540-020-00151-9. NPJ Syst Biol Appl. 2020. PMID: 33082337 Free PMC article.
Systems biology approach to functionally assess the Clostridioides difficile pangenome reveals genetic diversity with discriminatory power.
Norsigian CJ, Danhof HA, Brand CK, Midani FS, Broddrick JT, Savidge TC, Britton RA, Palsson BO, Spinler JK, Monk JM. Norsigian CJ, et al. Among authors: brand ck. Proc Natl Acad Sci U S A. 2022 May 3;119(18):e2119396119. doi: 10.1073/pnas.2119396119. Epub 2022 Apr 27. Proc Natl Acad Sci U S A. 2022. PMID: 35476524 Free PMC article.