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FMNL2 drives actin-based protrusion and migration downstream of Cdc42.
Block J, Breitsprecher D, Kühn S, Winterhoff M, Kage F, Geffers R, Duwe P, Rohn JL, Baum B, Brakebusch C, Geyer M, Stradal TE, Faix J, Rottner K. Block J, et al. Among authors: brakebusch c. Curr Biol. 2012 Jun 5;22(11):1005-12. doi: 10.1016/j.cub.2012.03.064. Epub 2012 May 17. Curr Biol. 2012. PMID: 22608513 Free PMC article.
FMNL formins boost lamellipodial force generation.
Kage F, Winterhoff M, Dimchev V, Mueller J, Thalheim T, Freise A, Brühmann S, Kollasser J, Block J, Dimchev G, Geyer M, Schnittler HJ, Brakebusch C, Stradal TE, Carlier MF, Sixt M, Käs J, Faix J, Rottner K. Kage F, et al. Among authors: brakebusch c. Nat Commun. 2017 Mar 22;8:14832. doi: 10.1038/ncomms14832. Nat Commun. 2017. PMID: 28327544 Free PMC article.
Rac function is crucial for cell migration but is not required for spreading and focal adhesion formation.
Steffen A, Ladwein M, Dimchev GA, Hein A, Schwenkmezger L, Arens S, Ladwein KI, Margit Holleboom J, Schur F, Victor Small J, Schwarz J, Gerhard R, Faix J, Stradal TE, Brakebusch C, Rottner K. Steffen A, et al. Among authors: brakebusch c. J Cell Sci. 2013 Oct 15;126(Pt 20):4572-88. doi: 10.1242/jcs.118232. Epub 2013 Jul 31. J Cell Sci. 2013. PMID: 23902686 Free PMC article.
188 results