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Safety Testing of an Antisense Oligonucleotide Intended for Pediatric Indications in the Juvenile Göttingen Minipig, including an Evaluation of the Ontogeny of Key Nucleases.
Valenzuela A, Tardiveau C, Ayuso M, Buyssens L, Bars C, Van Ginneken C, Fant P, Leconte I, Braendli-Baiocco A, Parrott N, Schmitt G, Tessier Y, Barrow P, Van Cruchten S. Valenzuela A, et al. Among authors: braendli baiocco a. Pharmaceutics. 2021 Sep 10;13(9):1442. doi: 10.3390/pharmaceutics13091442. Pharmaceutics. 2021. PMID: 34575518 Free PMC article.
From the Cover: The Minipig is a Suitable Non-Rodent Model in the Safety Assessment of Single Stranded Oligonucleotides.
Braendli-Baiocco A, Festag M, Dumong Erichsen K, Persson R, Mihatsch MJ, Fisker N, Funk J, Mohr S, Constien R, Ploix C, Brady K, Berrera M, Altmann B, Lenz B, Albassam M, Schmitt G, Weiser T, Schuler F, Singer T, Tessier Y. Braendli-Baiocco A, et al. Toxicol Sci. 2017 May 1;157(1):112-128. doi: 10.1093/toxsci/kfx025. Toxicol Sci. 2017. PMID: 28123102 Free PMC article.
Inhibition of EGF Uptake by Nephrotoxic Antisense Drugs In Vitro and Implications for Preclinical Safety Profiling.
Moisan A, Gubler M, Zhang JD, Tessier Y, Dumong Erichsen K, Sewing S, Gérard R, Avignon B, Huber S, Benmansour F, Chen X, Villaseñor R, Braendli-Baiocco A, Festag M, Maunz A, Singer T, Schuler F, Roth AB. Moisan A, et al. Among authors: braendli baiocco a. Mol Ther Nucleic Acids. 2017 Mar 17;6:89-105. doi: 10.1016/j.omtn.2016.11.006. Epub 2016 Dec 10. Mol Ther Nucleic Acids. 2017. PMID: 28325303 Free PMC article.
Safety, Tissue Distribution, and Metabolism of LNA-Containing Antisense Oligonucleotides in Rats.
Romero-Palomo F, Festag M, Lenz B, Schadt S, Brink A, Kipar A, Steinhuber B, Husser C, Koller E, Sewing S, Tessier Y, Dzygiel P, Fischer G, Winter M, Hetzel U, Mihatsch MJ, Braendli-Baiocco A. Romero-Palomo F, et al. Among authors: braendli baiocco a. Toxicol Pathol. 2021 Aug;49(6):1174-1192. doi: 10.1177/01926233211011615. Epub 2021 Jun 1. Toxicol Pathol. 2021. PMID: 34060347
International Harmonization of Nomenclature and Diagnostic Criteria (INHAND): Non-proliferative and Proliferative Lesions of the Non-human Primate (M. fascicularis).
Colman K, Andrews RN, Atkins H, Boulineau T, Bradley A, Braendli-Baiocco A, Capobianco R, Caudell D, Cline M, Doi T, Ernst R, van Esch E, Everitt J, Fant P, Gruebbel MM, Mecklenburg L, Miller AD, Nikula KJ, Satake S, Schwartz J, Sharma A, Shimoi A, Sobry C, Taylor I, Vemireddi V, Vidal J, Wood C, Vahle JL. Colman K, et al. Among authors: braendli baiocco a. J Toxicol Pathol. 2021;34(3 Suppl):1S-182S. doi: 10.1293/tox.34.1S. Epub 2021 Sep 28. J Toxicol Pathol. 2021. PMID: 34712008 Free PMC article. Review.
Characterizing Adversity of Lysosomal Accumulation in Nonclinical Toxicity Studies: Results from the 5th ESTP International Expert Workshop.
Lenz B, Braendli-Baiocco A, Engelhardt J, Fant P, Fischer H, Francke S, Fukuda R, Gröters S, Harada T, Harleman H, Kaufmann W, Kustermann S, Nolte T, Palazzi X, Pohlmeyer-Esch G, Popp A, Romeike A, Schulte A, Lima BS, Tomlinson L, Willard J, Wood CE, Yoshida M. Lenz B, et al. Among authors: braendli baiocco a. Toxicol Pathol. 2018 Feb;46(2):224-246. doi: 10.1177/0192623317749452. Toxicol Pathol. 2018. PMID: 29471779
Scientific and Regulatory Policy Committee Points to Consider: Histopathologic Evaluation in Safety Assessment Studies for PEGylated Pharmaceutical Products.
Irizarry Rovira AR, Bennet BM, Bolon B, Braendli-Baiocco A, Chandra S, Fleurance R, Garman R, Hutto D, Lane J, Romeike A, Sargeant A, Zimmerman B. Irizarry Rovira AR, et al. Among authors: braendli baiocco a. Toxicol Pathol. 2018 Aug;46(6):616-635. doi: 10.1177/0192623318791801. Epub 2018 Aug 9. Toxicol Pathol. 2018. PMID: 30092727 Review.
Characterization of post-surgical alterations in the bile duct-cannulated rat.
Bachir-Cherif D, Blum D, Braendli-Baiocco A, Chaput E, Pacheco GC, Flint N, Haiker M, Hoflack JC, Justies N, Neff R, Starke V, Steiner G, Tournillac CA, Singer T, Ubeaud-Séquier G, Schuler F. Bachir-Cherif D, et al. Xenobiotica. 2011 Aug;41(8):701-11. doi: 10.3109/00498254.2011.565819. Epub 2011 Apr 27. Xenobiotica. 2011. PMID: 21521079
12 results