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SPRTN is involved in hepatocellular carcinoma development through the ER stress response.
Batel A, Polović M, Glumac M, Šuman O, Jadrijević S, Lozić B, Petrović M, Samardžija B, Bradshaw NJ, Skube K, Palada V, Acman M, Marinović Terzić I. Batel A, et al. Among authors: bradshaw nj. Cancer Gene Ther. 2024 Mar;31(3):376-386. doi: 10.1038/s41417-023-00708-w. Epub 2023 Dec 12. Cancer Gene Ther. 2024. PMID: 38086993
A t(1;11) translocation linked to schizophrenia and affective disorders gives rise to aberrant chimeric DISC1 transcripts that encode structurally altered, deleterious mitochondrial proteins.
Eykelenboom JE, Briggs GJ, Bradshaw NJ, Soares DC, Ogawa F, Christie S, Malavasi EL, Makedonopoulou P, Mackie S, Malloy MP, Wear MA, Blackburn EA, Bramham J, McIntosh AM, Blackwood DH, Muir WJ, Porteous DJ, Millar JK. Eykelenboom JE, et al. Among authors: bradshaw nj. Hum Mol Genet. 2012 Aug 1;21(15):3374-86. doi: 10.1093/hmg/dds169. Epub 2012 Apr 30. Hum Mol Genet. 2012. PMID: 22547224 Free PMC article.
The DISC locus in psychiatric illness.
Chubb JE, Bradshaw NJ, Soares DC, Porteous DJ, Millar JK. Chubb JE, et al. Among authors: bradshaw nj. Mol Psychiatry. 2008 Jan;13(1):36-64. doi: 10.1038/sj.mp.4002106. Epub 2007 Oct 2. Mol Psychiatry. 2008. PMID: 17912248 Review.
36 results