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Multispecific Antibody Development Platform Based on Human Heavy Chain Antibodies.
Clarke SC, Ma B, Trinklein ND, Schellenberger U, Osborn MJ, Ouisse LH, Boudreau A, Davison LM, Harris KE, Ugamraj HS, Balasubramani A, Dang KH, Jorgensen B, Ogana HAN, Pham DT, Pratap PP, Sankaran P, Anegon I, van Schooten WC, Brüggemann M, Buelow R, Force Aldred S. Clarke SC, et al. Among authors: bruggemann m. Front Immunol. 2019 Jan 7;9:3037. doi: 10.3389/fimmu.2018.03037. eCollection 2018. Front Immunol. 2019. PMID: 30666250 Free PMC article.
Sequence-Based Discovery Demonstrates That Fixed Light Chain Human Transgenic Rats Produce a Diverse Repertoire of Antigen-Specific Antibodies.
Harris KE, Aldred SF, Davison LM, Ogana HAN, Boudreau A, Brüggemann M, Osborn M, Ma B, Buelow B, Clarke SC, Dang KH, Iyer S, Jorgensen B, Pham DT, Pratap PP, Rangaswamy US, Schellenberger U, van Schooten WC, Ugamraj HS, Vafa O, Buelow R, Trinklein ND. Harris KE, et al. Among authors: bruggemann m. Front Immunol. 2018 Apr 24;9:889. doi: 10.3389/fimmu.2018.00889. eCollection 2018. Front Immunol. 2018. PMID: 29740455 Free PMC article.
High-affinity IgG antibodies develop naturally in Ig-knockout rats carrying germline human IgH/Igκ/Igλ loci bearing the rat CH region.
Osborn MJ, Ma B, Avis S, Binnie A, Dilley J, Yang X, Lindquist K, Ménoret S, Iscache AL, Ouisse LH, Rajpal A, Anegon I, Neuberger MS, Buelow R, Brüggemann M. Osborn MJ, et al. Among authors: bruggemann m. J Immunol. 2013 Feb 15;190(4):1481-90. doi: 10.4049/jimmunol.1203041. Epub 2013 Jan 9. J Immunol. 2013. PMID: 23303672 Free PMC article.
Antigen-specific single B cell sorting and expression-cloning from immunoglobulin humanized rats: a rapid and versatile method for the generation of high affinity and discriminative human monoclonal antibodies.
Ouisse LH, Gautreau-Rolland L, Devilder MC, Osborn M, Moyon M, Visentin J, Halary F, Bruggemann M, Buelow R, Anegon I, Saulquin X. Ouisse LH, et al. Among authors: bruggemann m. BMC Biotechnol. 2017 Jan 9;17(1):3. doi: 10.1186/s12896-016-0322-5. BMC Biotechnol. 2017. PMID: 28081707 Free PMC article.
Characterization of immunoglobulin heavy chain knockout rats.
Ménoret S, Iscache AL, Tesson L, Rémy S, Usal C, Osborn MJ, Cost GJ, Brüggemann M, Buelow R, Anegon I. Ménoret S, et al. Among authors: bruggemann m. Eur J Immunol. 2010 Oct;40(10):2932-41. doi: 10.1002/eji.201040939. Eur J Immunol. 2010. PMID: 21038471 Free article.
Human antibody production in transgenic animals.
Brüggemann M, Osborn MJ, Ma B, Hayre J, Avis S, Lundstrom B, Buelow R. Brüggemann M, et al. Arch Immunol Ther Exp (Warsz). 2015 Apr;63(2):101-8. doi: 10.1007/s00005-014-0322-x. Epub 2014 Dec 3. Arch Immunol Ther Exp (Warsz). 2015. PMID: 25467949 Free PMC article. Review.
281 results