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A hydrogel-based in vitro assay for the fast prediction of antibiotic accumulation in Gram-negative bacteria.
Richter R, Kamal MAM, García-Rivera MA, Kaspar J, Junk M, Elgaher WAM, Srikakulam SK, Gress A, Beckmann A, Grißmer A, Meier C, Vielhaber M, Kalinina O, Hirsch AKH, Hartmann RW, Brönstrup M, Schneider-Daum N, Lehr CM. Richter R, et al. Among authors: bronstrup m. Mater Today Bio. 2020 Nov 2;8:100084. doi: 10.1016/j.mtbio.2020.100084. eCollection 2020 Sep. Mater Today Bio. 2020. PMID: 33313504 Free PMC article.
In Vitro Model of the Gram-Negative Bacterial Cell Envelope for Investigation of Anti-Infective Permeation Kinetics.
Graef F, Richter R, Fetz V, Murgia X, De Rossi C, Schneider-Daum N, Allegretta G, Elgaher W, Haupenthal J, Empting M, Beckmann F, Brönstrup M, Hartmann R, Gordon S, Lehr CM. Graef F, et al. Among authors: bronstrup m. ACS Infect Dis. 2018 Aug 10;4(8):1188-1196. doi: 10.1021/acsinfecdis.7b00165. Epub 2018 May 24. ACS Infect Dis. 2018. PMID: 29750862
Subcellular Quantification of Uptake in Gram-Negative Bacteria.
Prochnow H, Fetz V, Hotop SK, García-Rivera MA, Heumann A, Brönstrup M. Prochnow H, et al. Among authors: bronstrup m. Anal Chem. 2019 Feb 5;91(3):1863-1872. doi: 10.1021/acs.analchem.8b03586. Epub 2018 Dec 11. Anal Chem. 2019. PMID: 30485749
Semisynthesis and biological evaluation of amidochelocardin derivatives as broad-spectrum antibiotics.
Grandclaudon C, Birudukota NVS, Elgaher WAM, Jumde RP, Yahiaoui S, Arisetti N, Hennessen F, Hüttel S, Stadler M, Herrmann J, Miethke M, Hartmann RW, Müller R, Hirsch AKH, Brönstrup M. Grandclaudon C, et al. Among authors: bronstrup m. Eur J Med Chem. 2020 Feb 15;188:112005. doi: 10.1016/j.ejmech.2019.112005. Epub 2019 Dec 20. Eur J Med Chem. 2020. PMID: 31911294
Synthetic studies of cystobactamids as antibiotics and bacterial imaging carriers lead to compounds with high in vivo efficacy.
Testolin G, Cirnski K, Rox K, Prochnow H, Fetz V, Grandclaudon C, Mollner T, Baiyoumy A, Ritter A, Leitner C, Krull J, van den Heuvel J, Vassort A, Sordello S, Hamed MM, Elgaher WAM, Herrmann J, Hartmann RW, Müller R, Brönstrup M. Testolin G, et al. Among authors: bronstrup m. Chem Sci. 2019 Dec 10;11(5):1316-1334. doi: 10.1039/c9sc04769g. Chem Sci. 2019. PMID: 34123255 Free PMC article.
Towards the sustainable discovery and development of new antibiotics.
Miethke M, Pieroni M, Weber T, Brönstrup M, Hammann P, Halby L, Arimondo PB, Glaser P, Aigle B, Bode HB, Moreira R, Li Y, Luzhetskyy A, Medema MH, Pernodet JL, Stadler M, Tormo JR, Genilloud O, Truman AW, Weissman KJ, Takano E, Sabatini S, Stegmann E, Brötz-Oesterhelt H, Wohlleben W, Seemann M, Empting M, Hirsch AKH, Loretz B, Lehr CM, Titz A, Herrmann J, Jaeger T, Alt S, Hesterkamp T, Winterhalter M, Schiefer A, Pfarr K, Hoerauf A, Graz H, Graz M, Lindvall M, Ramurthy S, Karlén A, van Dongen M, Petkovic H, Keller A, Peyrane F, Donadio S, Fraisse L, Piddock LJV, Gilbert IH, Moser HE, Müller R. Miethke M, et al. Among authors: bronstrup m. Nat Rev Chem. 2021;5(10):726-749. doi: 10.1038/s41570-021-00313-1. Epub 2021 Aug 19. Nat Rev Chem. 2021. PMID: 34426795 Free PMC article. Review.
145 results