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An in-tumor genetic screen reveals that the BET bromodomain protein, BRD4, is a potential therapeutic target in ovarian carcinoma.
Baratta MG, Schinzel AC, Zwang Y, Bandopadhayay P, Bowman-Colin C, Kutt J, Curtis J, Piao H, Wong LC, Kung AL, Beroukhim R, Bradner JE, Drapkin R, Hahn WC, Liu JF, Livingston DM. Baratta MG, et al. Among authors: bowman colin c. Proc Natl Acad Sci U S A. 2015 Jan 6;112(1):232-7. doi: 10.1073/pnas.1422165112. Epub 2014 Dec 22. Proc Natl Acad Sci U S A. 2015. PMID: 25535366 Free PMC article.
BRCA1/Trp53 heterozygosity and replication stress drive esophageal cancer development in a mouse model.
He Y, Rivera J, Diossy M, Duan H, Bowman-Colin C, Reed R, Jennings R, Novak J, Tran SV, Cohen EF, Szuts D, Giobbie-Hurder A, Bronson RT, Bass AJ, Signoretti S, Szallasi Z, Livingston DM, Pathania S. He Y, et al. Among authors: bowman colin c. Proc Natl Acad Sci U S A. 2021 Oct 12;118(41):e2108421118. doi: 10.1073/pnas.2108421118. Proc Natl Acad Sci U S A. 2021. PMID: 34607954 Free PMC article.
Palb2 synergizes with Trp53 to suppress mammary tumor formation in a model of inherited breast cancer.
Bowman-Colin C, Xia B, Bunting S, Klijn C, Drost R, Bouwman P, Fineman L, Chen X, Culhane AC, Cai H, Rodig SJ, Bronson RT, Jonkers J, Nussenzweig A, Kanellopoulou C, Livingston DM. Bowman-Colin C, et al. Proc Natl Acad Sci U S A. 2013 May 21;110(21):8632-7. doi: 10.1073/pnas.1305362110. Epub 2013 May 8. Proc Natl Acad Sci U S A. 2013. PMID: 23657012 Free PMC article.
BRCA1 haploinsufficiency for replication stress suppression in primary cells.
Pathania S, Bade S, Le Guillou M, Burke K, Reed R, Bowman-Colin C, Su Y, Ting DT, Polyak K, Richardson AL, Feunteun J, Garber JE, Livingston DM. Pathania S, et al. Among authors: bowman colin c. Nat Commun. 2014 Nov 17;5:5496. doi: 10.1038/ncomms6496. Nat Commun. 2014. PMID: 25400221 Free PMC article.
Overexpression of BLM promotes DNA damage and increased sensitivity to platinum salts in triple-negative breast and serous ovarian cancers.
Birkbak NJ, Li Y, Pathania S, Greene-Colozzi A, Dreze M, Bowman-Colin C, Sztupinszki Z, Krzystanek M, Diossy M, Tung N, Ryan PD, Garber JE, Silver DP, Iglehart JD, Wang ZC, Szuts D, Szallasi Z, Richardson AL. Birkbak NJ, et al. Among authors: bowman colin c. Ann Oncol. 2018 Apr 1;29(4):903-909. doi: 10.1093/annonc/mdy049. Ann Oncol. 2018. PMID: 29452344 Free PMC article.
Isolation and characterization of novel RECK tumor suppressor gene splice variants.
Trombetta-Lima M, Winnischofer SM, Demasi MA, Astorino Filho R, Carreira AC, Wei B, de Assis-Ribas T, Konig MS, Bowman-Colin C, Oba-Shinjo SM, Marie SK, Stetler-Stevenson W, Sogayar MC. Trombetta-Lima M, et al. Among authors: bowman colin c. Oncotarget. 2015 Oct 20;6(32):33120-33. doi: 10.18632/oncotarget.5305. Oncotarget. 2015. PMID: 26431549 Free PMC article.
MAPK Pathway Suppression Unmasks Latent DNA Repair Defects and Confers a Chemical Synthetic Vulnerability in BRAF-, NRAS-, and NF1-Mutant Melanomas.
Maertens O, Kuzmickas R, Manchester HE, Emerson CE, Gavin AG, Guild CJ, Wong TC, De Raedt T, Bowman-Colin C, Hatchi E, Garraway LA, Flaherty KT, Pathania S, Elledge SJ, Cichowski K. Maertens O, et al. Among authors: bowman colin c. Cancer Discov. 2019 Apr;9(4):526-545. doi: 10.1158/2159-8290.CD-18-0879. Epub 2019 Feb 1. Cancer Discov. 2019. PMID: 30709805 Free PMC article.
15 results