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Thiopeptides Induce Proteasome-Independent Activation of Cellular Mitophagy.
Bird KE, Xander C, Murcia S, Schmalstig AA, Wang X, Emanuele MJ, Braunstein M, Bowers AA. Bird KE, et al. Among authors: bowers aa. ACS Chem Biol. 2020 Aug 21;15(8):2164-2174. doi: 10.1021/acschembio.0c00364. Epub 2020 Jul 14. ACS Chem Biol. 2020. PMID: 32589399 Free PMC article.
Thiolutin is a zinc chelator that inhibits the Rpn11 and other JAMM metalloproteases.
Lauinger L, Li J, Shostak A, Cemel IA, Ha N, Zhang Y, Merkl PE, Obermeyer S, Stankovic-Valentin N, Schafmeier T, Wever WJ, Bowers AA, Carter KP, Palmer AE, Tschochner H, Melchior F, Deshaies RJ, Brunner M, Diernfellner A. Lauinger L, et al. Among authors: bowers aa. Nat Chem Biol. 2017 Jul;13(7):709-714. doi: 10.1038/nchembio.2370. Epub 2017 May 1. Nat Chem Biol. 2017. PMID: 28459440 Free PMC article.
Flexizyme-Enabled Benchtop Biosynthesis of Thiopeptides.
Fleming SR, Bartges TE, Vinogradov AA, Kirkpatrick CL, Goto Y, Suga H, Hicks LM, Bowers AA. Fleming SR, et al. Among authors: bowers aa. J Am Chem Soc. 2019 Jan 16;141(2):758-762. doi: 10.1021/jacs.8b11521. Epub 2019 Jan 8. J Am Chem Soc. 2019. PMID: 30602112 Free PMC article.
73 results