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Obesity and hyperinsulinemia drive adipocytes to activate a cell cycle program and senesce.
Li Q, Hagberg CE, Silva Cascales H, Lang S, Hyvönen MT, Salehzadeh F, Chen P, Alexandersson I, Terezaki E, Harms MJ, Kutschke M, Arifen N, Krämer N, Aouadi M, Knibbe C, Boucher J, Thorell A, Spalding KL. Li Q, et al. Among authors: boucher j. Nat Med. 2021 Nov;27(11):1941-1953. doi: 10.1038/s41591-021-01501-8. Epub 2021 Oct 4. Nat Med. 2021. PMID: 34608330
Lipoxins reduce obesity-induced adipose tissue inflammation in 3D-cultured human adipocytes and explant cultures.
Soták M, Rajan MR, Clark M, Harms M, Rani A, Kraft JD, Tandio D, Shen T, Borkowski K, Fiehn O, Newman JW, Quiding-Järbrink M, Biörserud C, Apelgren P, Staalesen T, Hagberg CE, Boucher J, Wallenius V, Lange S, Börgeson E. Soták M, et al. Among authors: boucher j. iScience. 2022 Jun 11;25(7):104602. doi: 10.1016/j.isci.2022.104602. eCollection 2022 Jul 15. iScience. 2022. PMID: 35789845 Free PMC article.
Cellular senescence in hepatocytes contributes to metabolic disturbances in NASH.
Bonnet L, Alexandersson I, Baboota RK, Kroon T, Oscarsson J, Smith U, Boucher J. Bonnet L, et al. Among authors: boucher j. Front Endocrinol (Lausanne). 2022 Aug 22;13:957616. doi: 10.3389/fendo.2022.957616. eCollection 2022. Front Endocrinol (Lausanne). 2022. PMID: 36072934 Free PMC article.
Role of microRNA processing in adipose tissue in stress defense and longevity.
Mori MA, Raghavan P, Thomou T, Boucher J, Robida-Stubbs S, Macotela Y, Russell SJ, Kirkland JL, Blackwell TK, Kahn CR. Mori MA, et al. Among authors: boucher j. Cell Metab. 2012 Sep 5;16(3):336-47. doi: 10.1016/j.cmet.2012.07.017. Cell Metab. 2012. PMID: 22958919 Free PMC article.
Adipose-specific deletion of TFAM increases mitochondrial oxidation and protects mice against obesity and insulin resistance.
Vernochet C, Mourier A, Bezy O, Macotela Y, Boucher J, Rardin MJ, An D, Lee KY, Ilkayeva OR, Zingaretti CM, Emanuelli B, Smyth G, Cinti S, Newgard CB, Gibson BW, Larsson NG, Kahn CR. Vernochet C, et al. Among authors: boucher j. Cell Metab. 2012 Dec 5;16(6):765-76. doi: 10.1016/j.cmet.2012.10.016. Epub 2012 Nov 15. Cell Metab. 2012. PMID: 23168219 Free PMC article.
Enoxacin induces oxidative metabolism and mitigates obesity by regulating adipose tissue miRNA expression.
Rocha AL, de Lima TI, de Souza GP, Corrêa RO, Ferrucci DL, Rodrigues B, Lopes-Ramos C, Nilsson D, Knittel TL, Castro PR, Fernandes MF, Dos Santos Martins F, Parmigiani RB, Silveira LR, Carvalho HF, Auwerx J, Vinolo MAR, Boucher J, Mori MA. Rocha AL, et al. Among authors: boucher j. Sci Adv. 2020 Dec 2;6(49):eabc6250. doi: 10.1126/sciadv.abc6250. Print 2020 Dec. Sci Adv. 2020. PMID: 33268375 Free PMC article.
776 results