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Novel broad spectrum virucidal molecules against enveloped viruses.
Cagno V, Tintori C, Civra A, Cavalli R, Tiberi M, Botta L, Brai A, Poli G, Tapparel C, Lembo D, Botta M. Cagno V, et al. Among authors: botta m, botta l. PLoS One. 2018 Dec 7;13(12):e0208333. doi: 10.1371/journal.pone.0208333. eCollection 2018. PLoS One. 2018. PMID: 30532192 Free PMC article.
Rhodanine derivatives as potent anti-HIV and anti-HSV microbicides.
Tintori C, Iovenitti G, Ceresola ER, Ferrarese R, Zamperini C, Brai A, Poli G, Dreassi E, Cagno V, Lembo D, Canducci F, Botta M. Tintori C, et al. Among authors: botta m. PLoS One. 2018 Jun 5;13(6):e0198478. doi: 10.1371/journal.pone.0198478. eCollection 2018. PLoS One. 2018. PMID: 29870553 Free PMC article.
Human DDX3 protein is a valuable target to develop broad spectrum antiviral agents.
Brai A, Fazi R, Tintori C, Zamperini C, Bugli F, Sanguinetti M, Stigliano E, Esté J, Badia R, Franco S, Martinez MA, Martinez JP, Meyerhans A, Saladini F, Zazzi M, Garbelli A, Maga G, Botta M. Brai A, et al. Among authors: botta m. Proc Natl Acad Sci U S A. 2016 May 10;113(19):5388-93. doi: 10.1073/pnas.1522987113. Epub 2016 Apr 26. Proc Natl Acad Sci U S A. 2016. PMID: 27118832 Free PMC article.
2-Aminothiazolones as anti-HIV agents that act as gp120-CD4 inhibitors.
Tiberi M, Tintori C, Ceresola ER, Fazi R, Zamperini C, Calandro P, Franchi L, Selvaraj M, Botta L, Sampaolo M, Saita D, Ferrarese R, Clementi M, Canducci F, Botta M. Tiberi M, et al. Among authors: botta m, botta l. Antimicrob Agents Chemother. 2014 Jun;58(6):3043-52. doi: 10.1128/AAC.02739-13. Epub 2014 Mar 10. Antimicrob Agents Chemother. 2014. PMID: 24614386 Free PMC article.
Development and in Vitro Evaluation of a Microbicide Gel Formulation for a Novel Non-Nucleoside Reverse Transcriptase Inhibitor Belonging to the N-Dihydroalkyloxybenzyloxopyrimidines (N-DABOs) Family.
Tintori C, Brai A, Dasso Lang MC, Deodato D, Greco AM, Bizzarri BM, Cascone L, Casian A, Zamperini C, Dreassi E, Crespan E, Maga G, Vanham G, Ceresola E, Canducci F, Ariën KK, Botta M. Tintori C, et al. Among authors: botta m. J Med Chem. 2016 Mar 24;59(6):2747-59. doi: 10.1021/acs.jmedchem.5b01979. Epub 2016 Mar 8. J Med Chem. 2016. PMID: 26898379 Free article.
DDX3X Helicase Inhibitors as a New Strategy To Fight the West Nile Virus Infection.
Brai A, Martelli F, Riva V, Garbelli A, Fazi R, Zamperini C, Pollutri A, Falsitta L, Ronzini S, Maccari L, Maga G, Giannecchini S, Botta M. Brai A, et al. Among authors: botta m. J Med Chem. 2019 Mar 14;62(5):2333-2347. doi: 10.1021/acs.jmedchem.8b01403. Epub 2019 Feb 21. J Med Chem. 2019. PMID: 30721061
DDX3 inhibitors show antiviral activity against positive-sense single-stranded RNA viruses but not against negative-sense single-stranded RNA viruses: The coxsackie B model.
Quaranta P, Lottini G, Chesi G, Contrafatto F, Russotto R, Macera L, Lai M, Spezia PG, Brai A, Botta M, Freer G, Pistello M. Quaranta P, et al. Among authors: botta m. Antiviral Res. 2020 Jun;178:104750. doi: 10.1016/j.antiviral.2020.104750. Epub 2020 Mar 20. Antiviral Res. 2020. PMID: 32205137
Synthesis and Antiviral Activity of Novel 1,3,4-Thiadiazole Inhibitors of DDX3X.
Brai A, Ronzini S, Riva V, Botta L, Zamperini C, Borgini M, Trivisani CI, Garbelli A, Pennisi C, Boccuto A, Saladini F, Zazzi M, Maga G, Botta M. Brai A, et al. Among authors: botta m, botta l. Molecules. 2019 Nov 4;24(21):3988. doi: 10.3390/molecules24213988. Molecules. 2019. PMID: 31690062 Free PMC article.
723 results