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Frentizole derivatives with mTOR inhibiting and senomorphic properties.
Chrienova Z, Rysanek D, Novak J, Vasicova P, Oleksak P, Andrys R, Skarka A, Dumanovic J, Milovanovic Z, Jacevic V, Chvojkova M, Holubova K, Vales K, Skoupilova V, Valko M, Jomova K, Alomar SY, Botelho FD, Franca TCC, Kuca K, Hodny Z, Nepovimova E. Chrienova Z, et al. Among authors: botelho fd. Biomed Pharmacother. 2023 Nov;167:115600. doi: 10.1016/j.biopha.2023.115600. Epub 2023 Sep 30. Biomed Pharmacother. 2023. PMID: 37783152 Free article.
Searching for potential drugs against SARS-CoV-2 through virtual screening on several molecular targets.
Almeida JSFD, Botelho FD, de Souza FR, Dos Santos MC, Goncalves ADS, Rodrigues RLB, Cardozo M, Kitagawa DAS, Vieira LA, Silva RSF, Cavalcante SFA, Bastos LDC, Nogueira MOT, de Santana PIR, Brum JOC, Nepovimova E, Kuca K, LaPlante SR, Galante EBF, Franca TCC. Almeida JSFD, et al. Among authors: botelho fd. J Biomol Struct Dyn. 2022 Jul;40(11):5229-5242. doi: 10.1080/07391102.2020.1869096. Epub 2021 Jan 8. J Biomol Struct Dyn. 2022. PMID: 33416020 Free PMC article.
Are the current commercially available oximes capable of reactivating acetylcholinesterase inhibited by the nerve agents of the A-series?
Santos MC, Botelho FD, Gonçalves AS, Kitagawa DAS, Borges CVN, Carvalho-Silva T, Bernardo LB, Ferreira CN, Rodrigues RB, Ferreira Neto DC, Nepovimova E, Kuča K, LaPlante SR, Lima ALS, França TCC, Cavalcante SFA. Santos MC, et al. Among authors: botelho fd. Arch Toxicol. 2022 Sep;96(9):2559-2572. doi: 10.1007/s00204-022-03316-z. Epub 2022 Jun 6. Arch Toxicol. 2022. PMID: 35666269
N-substituted arylhydroxamic acids as acetylcholinesterase reactivators.
Bondar D, Kapitanov IV, Pulkrabkova L, Soukup O, Jun D, Botelho FD, França TCC, Kuča K, Karpichev Y. Bondar D, et al. Among authors: botelho fd. Chem Biol Interact. 2022 Sep 25;365:110078. doi: 10.1016/j.cbi.2022.110078. Epub 2022 Aug 5. Chem Biol Interact. 2022. PMID: 35940282
12 results