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LRH-1 agonism favours an immune-islet dialogue which protects against diabetes mellitus.
Cobo-Vuilleumier N, Lorenzo PI, Rodríguez NG, Herrera Gómez IG, Fuente-Martin E, López-Noriega L, Mellado-Gil JM, Romero-Zerbo SY, Baquié M, Lachaud CC, Stifter K, Perdomo G, Bugliani M, De Tata V, Bosco D, Parnaud G, Pozo D, Hmadcha A, Florido JP, Toscano MG, de Haan P, Schoonjans K, Sánchez Palazón L, Marchetti P, Schirmbeck R, Martín-Montalvo A, Meda P, Soria B, Bermúdez-Silva FJ, St-Onge L, Gauthier BR. Cobo-Vuilleumier N, et al. Among authors: bosco d. Nat Commun. 2018 Apr 16;9(1):1488. doi: 10.1038/s41467-018-03943-0. Nat Commun. 2018. PMID: 29662071 Free PMC article.
The Fas pathway is involved in pancreatic beta cell secretory function.
Schumann DM, Maedler K, Franklin I, Konrad D, Størling J, Böni-Schnetzler M, Gjinovci A, Kurrer MO, Gauthier BR, Bosco D, Andres A, Berney T, Greter M, Becher B, Chervonsky AV, Halban PA, Mandrup-Poulsen T, Wollheim CB, Donath MY. Schumann DM, et al. Among authors: bosco d. Proc Natl Acad Sci U S A. 2007 Feb 20;104(8):2861-6. doi: 10.1073/pnas.0611487104. Epub 2007 Feb 13. Proc Natl Acad Sci U S A. 2007. PMID: 17299038 Free PMC article.
Cx36 makes channels coupling human pancreatic beta-cells, and correlates with insulin expression.
Serre-Beinier V, Bosco D, Zulianello L, Charollais A, Caille D, Charpantier E, Gauthier BR, Diaferia GR, Giepmans BN, Lupi R, Marchetti P, Deng S, Buhler L, Berney T, Cirulli V, Meda P. Serre-Beinier V, et al. Among authors: bosco d. Hum Mol Genet. 2009 Feb 1;18(3):428-39. doi: 10.1093/hmg/ddn370. Epub 2008 Nov 10. Hum Mol Genet. 2009. PMID: 19000992 Free PMC article.
Regulated laminin-332 expression in human islets of Langerhans.
Armanet M, Wojtusciszyn A, Morel P, Parnaud G, Rousselle P, Sinigaglia C, Berney T, Bosco D. Armanet M, et al. Among authors: bosco d. FASEB J. 2009 Dec;23(12):4046-55. doi: 10.1096/fj.08-127142. Epub 2009 Aug 10. FASEB J. 2009. PMID: 19667121
493 results