Boschi D - Search Results

1

Use of human Dihydroorotate Dehydrogenase (hDHODH) Inhibitors in Autoimmune Diseases and New Perspectives in Cancer Therapy.

Lolli ML, Sainas S, Pippione AC, Giorgis M, Boschi D, Dosio F. Lolli ML, et al. Among authors: boschi d. Recent Pat Anticancer Drug Discov. 2018;13(1):86-105. doi: 10.2174/1574892812666171108124218. Recent Pat Anticancer Drug Discov. 2018. PMID: 29119937 Review.

2

Studies on agents with mixed NO-dependent vasodilating and beta-blocking activities.

Boschi D, Di Stilo A, Cena C, Lolli M, Fruttero R, Gasco A. Boschi D, et al. Pharm Res. 1997 Dec;14(12):1750-8. doi: 10.1023/a:1012136030849. Pharm Res. 1997. PMID: 9453064

3

NO-donor phenols: a new class of products endowed with antioxidant and vasodilator properties.

Boschi D, Tron GC, Lazzarato L, Chegaev K, Cena C, Di Stilo A, Giorgis M, Bertinaria M, Fruttero R, Gasco A. Boschi D, et al. J Med Chem. 2006 May 18;49(10):2886-97. doi: 10.1021/jm0510530. J Med Chem. 2006. PMID: 16686532

4

Multitarget drugs: synthesis and preliminary pharmacological characterization of zileuton analogues endowed with Dual 5-LO inhibitor and NO-dependent activities.

Boschi D, Giorgis M, Cena C, Talniya NC, Di Stilo A, Morini G, Coruzzi G, Guaita E, Fruttero R, Gasco A. Boschi D, et al. ChemMedChem. 2010 Sep 3;5(9):1444-9. doi: 10.1002/cmdc.201000198. ChemMedChem. 2010. PMID: 20645382 Free article. No abstract available.

5

Heterocyclic ring cleavage upon collision-induced dissociation of deprotonated 3-hydroxy-1,2,5-oxadiazoles (3-hydroxyfurazans).

Grossert JS, Pippione AC, Boschi D, Lolli ML, White RL. Grossert JS, et al. Among authors: boschi d. J Mass Spectrom. 2015 Dec;50(12):1433-7. doi: 10.1002/jms.3724. J Mass Spectrom. 2015. PMID: 26634978

6

Design, synthesis, biological evaluation and X-ray structural studies of potent human dihydroorotate dehydrogenase inhibitors based on hydroxylated azole scaffolds.

Sainas S, Pippione AC, Giorgis M, Lupino E, Goyal P, Ramondetti C, Buccinnà B, Piccinini M, Braga RC, Andrade CH, Andersson M, Moritzer AC, Friemann R, Mensa S, Al-Kadaraghi S, Boschi D, Lolli ML. Sainas S, et al. Among authors: boschi d. Eur J Med Chem. 2017 Mar 31;129:287-302. doi: 10.1016/j.ejmech.2017.02.017. Epub 2017 Feb 14. Eur J Med Chem. 2017. PMID: 28235702

7

Hydroxytriazole derivatives as potent and selective aldo-keto reductase 1C3 (AKR1C3) inhibitors discovered by bioisosteric scaffold hopping approach.

Pippione AC, Giraudo A, Bonanni D, Carnovale IM, Marini E, Cena C, Costale A, Zonari D, Pors K, Sadiq M, Boschi D, Oliaro-Bosso S, Lolli ML. Pippione AC, et al. Among authors: boschi d. Eur J Med Chem. 2017 Oct 20;139:936-946. doi: 10.1016/j.ejmech.2017.08.046. Epub 2017 Aug 24. Eur J Med Chem. 2017. PMID: 28881288 Free article.

8

Potent and selective aldo-keto reductase 1C3 (AKR1C3) inhibitors based on the benzoisoxazole moiety: application of a bioisosteric scaffold hopping approach to flufenamic acid.

Pippione AC, Carnovale IM, Bonanni D, Sini M, Goyal P, Marini E, Pors K, Adinolfi S, Zonari D, Festuccia C, Wahlgren WY, Friemann R, Bagnati R, Boschi D, Oliaro-Bosso S, Lolli ML. Pippione AC, et al. Among authors: boschi d. Eur J Med Chem. 2018 Apr 25;150:930-945. doi: 10.1016/j.ejmech.2018.03.040. Epub 2018 Mar 16. Eur J Med Chem. 2018. PMID: 29602039

9

Fragmentation pathways arising from protonation at different sites in aminoalkyl-substituted 3-hydroxy-1,2,5-oxadiazoles (3-hydroxyfurazans).

Grossert JS, Boschi D, Lolli ML, White RL. Grossert JS, et al. Among authors: boschi d. Rapid Commun Mass Spectrom. 2018 Aug 30;32(16):1403-1413. doi: 10.1002/rcm.8166. Rapid Commun Mass Spectrom. 2018. PMID: 29756659

10

Targeting Myeloid Differentiation Using Potent 2-Hydroxypyrazolo[1,5- a]pyridine Scaffold-Based Human Dihydroorotate Dehydrogenase Inhibitors.

Sainas S, Pippione AC, Lupino E, Giorgis M, Circosta P, Gaidano V, Goyal P, Bonanni D, Rolando B, Cignetti A, Ducime A, Andersson M, Järvå M, Friemann R, Piccinini M, Ramondetti C, Buccinnà B, Al-Karadaghi S, Boschi D, Saglio G, Lolli ML. Sainas S, et al. Among authors: boschi d. J Med Chem. 2018 Jul 26;61(14):6034-6055. doi: 10.1021/acs.jmedchem.8b00373. Epub 2018 Jul 9. J Med Chem. 2018. PMID: 29939742

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