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Page 1
Discovery of Inhibitory Fragments That Selectively Target Spire2-FMN2 Interaction.
Kitel R, Surmiak E, Borggräfe J, Kalinowska-Tluscik J, Golik P, Czub M, Uzar W, Musielak B, Madej M, Popowicz GM, Dubin G, Holak TA. Kitel R, et al. Among authors: borggrafe j. J Med Chem. 2023 Dec 14;66(23):15715-15727. doi: 10.1021/acs.jmedchem.3c00877. Epub 2023 Dec 1. J Med Chem. 2023. PMID: 38039505 Free PMC article.
Pharmacological perturbation of the phase-separating protein SMNDC1.
Enders L, Siklos M, Borggräfe J, Gaussmann S, Koren A, Malik M, Tomek T, Schuster M, Reiniš J, Hahn E, Rukavina A, Reicher A, Casteels T, Bock C, Winter GE, Hannich JT, Sattler M, Kubicek S. Enders L, et al. Among authors: borggrafe j. Nat Commun. 2023 Aug 16;14(1):4504. doi: 10.1038/s41467-023-40124-0. Nat Commun. 2023. PMID: 37587144 Free PMC article.
Phase separation of FSP1 promotes ferroptosis.
Nakamura T, Hipp C, Santos Dias Mourão A, Borggräfe J, Aldrovandi M, Henkelmann B, Wanninger J, Mishima E, Lytton E, Emler D, Proneth B, Sattler M, Conrad M. Nakamura T, et al. Among authors: borggrafe j. Nature. 2023 Jul;619(7969):371-377. doi: 10.1038/s41586-023-06255-6. Epub 2023 Jun 28. Nature. 2023. PMID: 37380771 Free PMC article.
Time-resolved structural analysis of an RNA-cleaving DNA catalyst.
Borggräfe J, Victor J, Rosenbach H, Viegas A, Gertzen CGW, Wuebben C, Kovacs H, Gopalswamy M, Riesner D, Steger G, Schiemann O, Gohlke H, Span I, Etzkorn M. Borggräfe J, et al. Nature. 2022 Jan;601(7891):144-149. doi: 10.1038/s41586-021-04225-4. Epub 2021 Dec 23. Nature. 2022. PMID: 34949858
Local Deuteration Enables NMR Observation of Methyl Groups in Proteins from Eukaryotic and Cell-Free Expression Systems.
Dubey A, Stoyanov N, Viennet T, Chhabra S, Elter S, Borggräfe J, Viegas A, Nowak RP, Burdzhiev N, Petrov O, Fischer ES, Etzkorn M, Gelev V, Arthanari H. Dubey A, et al. Among authors: borggrafe j. Angew Chem Int Ed Engl. 2021 Jun 14;60(25):13783-13787. doi: 10.1002/anie.202016070. Epub 2021 May 6. Angew Chem Int Ed Engl. 2021. PMID: 33768661 Free PMC article.