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4-(1H-Pyrazol-1-yl) benzenesulfonamide derivatives: identifying new active antileishmanial structures for use against a neglected disease.
Marra RK, Bernardino AM, Proux TA, Charret KS, Lira ML, Castro HC, Souza AM, Oliveira CD, Borges JC, Rodrigues CR, Canto-Cavalheiro MM, Leon LL, Amaral VF. Marra RK, et al. Among authors: borges jc. Molecules. 2012 Nov 1;17(11):12961-73. doi: 10.3390/molecules171112961. Molecules. 2012. PMID: 23117435 Free PMC article.
Design, synthesis, SAR, and biological evaluation of new 4-(phenylamino)thieno[2,3-b]pyridine derivatives.
Bernardino AM, da Silva Pinheiro LC, Rodrigues CR, Loureiro NI, Castro HC, Lanfredi-Rangel A, Sabatini-Lopes J, Borges JC, Carvalho JM, Romeiro GA, Ferreira VF, Frugulhetti IC, Vannier-Santos MA. Bernardino AM, et al. Among authors: borges jc. Bioorg Med Chem. 2006 Aug 15;14(16):5765-70. doi: 10.1016/j.bmc.2006.03.013. Epub 2006 Jun 14. Bioorg Med Chem. 2006. PMID: 16781157
Antibacterial profile against drug-resistant Staphylococcus epidermidis clinical strain and structure-activity relationship studies of 1H-pyrazolo[3,4-b]pyridine and thieno[2,3-b]pyridine derivatives.
Leal B, Afonso IF, Rodrigues CR, Abreu PA, Garrett R, Pinheiro LC, Azevedo AR, Borges JC, Vegi PF, Santos CC, da Silveira FC, Cabral LM, Frugulhetti IC, Bernardino AM, Santos DO, Castro HC. Leal B, et al. Among authors: borges jc. Bioorg Med Chem. 2008 Sep 1;16(17):8196-204. doi: 10.1016/j.bmc.2008.07.035. Epub 2008 Jul 20. Bioorg Med Chem. 2008. PMID: 18701299
Identification of a potential lead structure for designing new antimicrobials to treat infections caused by Staphylococcus epidermidis-resistant strains.
Pinheiro LC, Abreu PA, Afonso IF, Leal B, Corrêa LC, Borges JC, Marques IP, Lourenço AL, Sathler P, dos Santos AL, Medeiros CA, Cabral LM, Júnior ML, Romeiro GA, Ferreira VF, Rodrigues CR, Castro HC, Bernardino AM. Pinheiro LC, et al. Among authors: borges jc. Curr Microbiol. 2008 Nov;57(5):463-8. doi: 10.1007/s00284-008-9234-5. Epub 2008 Sep 23. Curr Microbiol. 2008. PMID: 18810543
Thieno[2,3-b]pyridine derivatives: a new class of antiviral drugs against Mayaro virus.
Amorim R, de Meneses MDF, Borges JC, da Silva Pinheiro LC, Caldas LA, Cirne-Santos CC, de Mello MVP, de Souza AMT, Castro HC, de Palmer Paixão ICN, Campos RM, Bergmann IE, Malirat V, Bernardino AMR, Rebello MA, Ferreira DF. Amorim R, et al. Among authors: borges jc. Arch Virol. 2017 Jun;162(6):1577-1587. doi: 10.1007/s00705-017-3261-0. Epub 2017 Feb 17. Arch Virol. 2017. PMID: 28213871
Interactions between 4-aminoquinoline and heme: Promising mechanism against Trypanosoma cruzi.
Lechuga GC, Borges JC, Calvet CM, de Araújo HP, Zuma AA, do Nascimento SB, Motta MCM, Bernardino AMR, Pereira MCS, Bourguignon SC. Lechuga GC, et al. Among authors: borges jc. Int J Parasitol Drugs Drug Resist. 2016 Dec;6(3):154-164. doi: 10.1016/j.ijpddr.2016.07.001. Epub 2016 Jul 14. Int J Parasitol Drugs Drug Resist. 2016. PMID: 27490082 Free PMC article.
PtII, PdII and AuIII complexes with a thiosemicarbazone derived from diacethylmonooxime: Structural analysis, trypanocidal activity, cytotoxicity and first insight into the antiparasitic mechanism of action.
Gonçalves ACR, Carneiro ZA, Oliveira CG, Danuello A, Guerra W, Oliveira RJ, Ferreira FB, Veloso-Silva LLW, Batista FAH, Borges JC, de Albuquerque S, Deflon VM, Maia PIS. Gonçalves ACR, et al. Among authors: borges jc. Eur J Med Chem. 2017 Dec 1;141:615-631. doi: 10.1016/j.ejmech.2017.10.013. Epub 2017 Oct 12. Eur J Med Chem. 2017. PMID: 29107428
Low resolution structural studies indicate that the activator of Hsp90 ATPase 1 (Aha1) of Leishmania braziliensis has an elongated shape which allows its interaction with both N- and M-domains of Hsp90.
Seraphim TV, Alves MM, Silva IM, Gomes FE, Silva KP, Murta SM, Barbosa LR, Borges JC. Seraphim TV, et al. Among authors: borges jc. PLoS One. 2013 Jun 24;8(6):e66822. doi: 10.1371/journal.pone.0066822. Print 2013. PLoS One. 2013. PMID: 23826147 Free PMC article.
147 results