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Blocking the CTLA-4 and PD-1 pathways during pulmonary paracoccidioidomycosis improves immunity, reduces disease severity, and increases the survival of infected mice.
Preite NW, Borges BM, Kaminski VL, Ayupe MC, Gonçalves LM, Dos Santos BV, Fonseca DLM, Filgueiras IS, Salgado CL, Muxel SM, Cabral-Marques O, da Fonseca DM, Loures FV, Calich VLG. Preite NW, et al. Among authors: borges bm. Front Immunol. 2024 Mar 4;15:1347318. doi: 10.3389/fimmu.2024.1347318. eCollection 2024. Front Immunol. 2024. PMID: 38500881 Free PMC article.
Transcriptional profiling of a fungal granuloma reveals a low metabolic activity of Paracoccidioides brasiliensis yeasts and an actively regulated host immune response.
Borges BM, Ramos RBC, Preite NW, Kaminski VL, Alves de Castro P, Camacho M, Maximo MF, Fill TP, Calich VLG, Traynor AM, Sarikaya-Bayram Ö, Doyle S, Bayram Ö, de Campos CBL, Zelanis A, Goldman GH, Loures FV. Borges BM, et al. Front Cell Infect Microbiol. 2023 Oct 5;13:1268959. doi: 10.3389/fcimb.2023.1268959. eCollection 2023. Front Cell Infect Microbiol. 2023. PMID: 37868350 Free PMC article.