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Cyclic AMP-binding protein Epac1 acts as a metabolic sensor to promote cardiomyocyte lipotoxicity.
Laudette M, Sainte-Marie Y, Cousin G, Bergonnier D, Belhabib I, Brun S, Formoso K, Laib L, Tortosa F, Bergoglio C, Marcheix B, Borén J, Lairez O, Fauconnier J, Lucas A, Mialet-Perez J, Moro C, Lezoualc'h F. Laudette M, et al. Among authors: boren j. Cell Death Dis. 2021 Sep 1;12(9):824. doi: 10.1038/s41419-021-04113-9. Cell Death Dis. 2021. PMID: 34471096 Free PMC article.
Cardiomyocyte-specific PCSK9 deficiency compromises mitochondrial bioenergetics and heart function.
Laudette M, Lindbom M, Arif M, Cinato M, Ruiz M, Doran S, Miljanovic A, Rutberg M, Andersson L, Klevstig M, Henricsson M, Bergh PO, Bollano E, Aung N, Gustav Smith J, Pilon M, Hyötyläinen T, Orešič M, Perkins R, Mardinoglu A, Levin MC, Borén J. Laudette M, et al. Among authors: boren j. Cardiovasc Res. 2023 Jul 4;119(7):1537-1552. doi: 10.1093/cvr/cvad041. Cardiovasc Res. 2023. PMID: 36880401 Free PMC article.
Glucosylceramide synthase deficiency in the heart compromises β1-adrenergic receptor trafficking.
Andersson L, Cinato M, Mardani I, Miljanovic A, Arif M, Koh A, Lindbom M, Laudette M, Bollano E, Omerovic E, Klevstig M, Henricsson M, Fogelstrand P, Swärd K, Ekstrand M, Levin M, Wikström J, Doran S, Hyötyläinen T, Sinisalu L, Orešič M, Tivesten Å, Adiels M, Bergo MO, Proia R, Mardinoglu A, Jeppsson A, Borén J, Levin MC. Andersson L, et al. Among authors: boren j. Eur Heart J. 2021 Nov 14;42(43):4481-4492. doi: 10.1093/eurheartj/ehab412. Eur Heart J. 2021. PMID: 34297830 Free PMC article.
Deficiency in perilipin 5 reduces mitochondrial function and membrane depolarization in mouse hearts.
Andersson L, Drevinge C, Mardani I, Dalen KT, Ståhlman M, Klevstig M, Lundqvist A, Haugen F, Adiels M, Fogelstrand P, Asin-Cayuela J, Hultén LM, Levin M, Ehrenborg E, Lee YK, Kimmel AR, Borén J, Levin MC. Andersson L, et al. Among authors: boren j. Int J Biochem Cell Biol. 2017 Oct;91(Pt A):9-13. doi: 10.1016/j.biocel.2017.07.021. Epub 2017 Aug 12. Int J Biochem Cell Biol. 2017. PMID: 28811250
The VLDL receptor promotes lipotoxicity and increases mortality in mice following an acute myocardial infarction.
Perman JC, Boström P, Lindbom M, Lidberg U, StÅhlman M, Hägg D, Lindskog H, Scharin Täng M, Omerovic E, Mattsson Hultén L, Jeppsson A, Petursson P, Herlitz J, Olivecrona G, Strickland DK, Ekroos K, Olofsson SO, Borén J. Perman JC, et al. Among authors: boren j. J Clin Invest. 2011 Jul;121(7):2625-40. doi: 10.1172/JCI43068. Epub 2011 Jun 13. J Clin Invest. 2011. PMID: 21670500 Free PMC article.
PLD1 and ERK2 regulate cytosolic lipid droplet formation.
Andersson L, Boström P, Ericson J, Rutberg M, Magnusson B, Marchesan D, Ruiz M, Asp L, Huang P, Frohman MA, Borén J, Olofsson SO. Andersson L, et al. Among authors: boren j. J Cell Sci. 2006 Jun 1;119(Pt 11):2246-57. doi: 10.1242/jcs.02941. J Cell Sci. 2006. PMID: 16723731
Broad Views of Non-alcoholic Fatty Liver Disease.
Mardinoglu A, Uhlen M, Borén J. Mardinoglu A, et al. Among authors: boren j. Cell Syst. 2018 Jan 24;6(1):7-9. doi: 10.1016/j.cels.2018.01.004. Cell Syst. 2018. PMID: 29401451 Free article.
477 results