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Novel D2/5-HT receptor modulators related to cariprazine with potential implication to schizophrenia treatment.
Juza R, Vojtechova I, Stefkova-Mazochova K, Dehaen W, Petrasek T, Prchal L, Kobrlova T, Janousek J, Vlcek P, Mezeiova E, Svozil D, Karasova JZ, Pejchal J, Stark H, Satala G, Bojarski AJ, Kubacka M, Mogilski S, Randakova A, Musilek K, Soukup O, Korabecny J. Juza R, et al. Among authors: bojarski aj. Eur J Med Chem. 2022 Mar 15;232:114193. doi: 10.1016/j.ejmech.2022.114193. Epub 2022 Feb 9. Eur J Med Chem. 2022. PMID: 35176563
Synthesis and pharmacological evaluation of new arylpiperazines. 3-[4-[4-(3-chlorophenyl)-1-piperazinyl]butyl]-quinazolidin-4-one - a dual serotonin 5-HT(1A)/5-HT(2A) receptor ligand with an anxiolytic-like activity.
Bojarski AJ, Kowalski P, Kowalska T, Duszyńska B, Charakchieva-Minol S, Tatarczyńska E, Kłodzińska A, Chojnacka-Wójcik E. Bojarski AJ, et al. Bioorg Med Chem. 2002 Dec;10(12):3817-27. doi: 10.1016/s0968-0896(02)00349-8. Bioorg Med Chem. 2002. PMID: 12413835
New arylpiperazine 5-HT(1A) receptor ligands containing the pyrimido[2,1-f]purine fragment: synthesis, in vitro, and in vivo pharmacological evaluation.
Jurczyk S, Kołaczkowski M, Maryniak E, Zajdel P, Pawłowski M, Tatarczyńska E, Kłodzińska A, Chojnacka-Wójcik E, Bojarski AJ, Charakchieva-Minol S, Duszyńska B, Nowak G, Maciag D. Jurczyk S, et al. Among authors: bojarski aj. J Med Chem. 2004 May 6;47(10):2659-66. doi: 10.1021/jm030946u. J Med Chem. 2004. PMID: 15115407
1-Aryl-4-(4-succinimidobutyl)piperazines and their conformationally constrained analogues: synthesis, binding to serotonin (5-HT1A, 5-HT2A, 5-HT7), alpha1-adrenergic, and dopaminergic D2 receptors, and in vivo 5-HT1A functional characteristics.
Bojarski AJ, Paluchowska MH, Duszyńska B, Kłodzińska A, Tatarczyńska E, Chojnacka-Wójcik E. Bojarski AJ, et al. Bioorg Med Chem. 2005 Mar 15;13(6):2293-303. doi: 10.1016/j.bmc.2004.12.041. Bioorg Med Chem. 2005. PMID: 15727878
234 results