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SIRT6 inhibitors with salicylate-like structure show immunosuppressive and chemosensitizing effects.
Damonte P, Sociali G, Parenti MD, Soncini D, Bauer I, Boero S, Grozio A, Holtey MV, Piacente F, Becherini P, Sanguineti R, Salis A, Damonte G, Cea M, Murone M, Poggi A, Nencioni A, Del Rio A, Bruzzone S. Damonte P, et al. Among authors: boero s. Bioorg Med Chem. 2017 Oct 15;25(20):5849-5858. doi: 10.1016/j.bmc.2017.09.023. Epub 2017 Sep 19. Bioorg Med Chem. 2017. PMID: 28958848
Quinazolinedione SIRT6 inhibitors sensitize cancer cells to chemotherapeutics.
Sociali G, Galeno L, Parenti MD, Grozio A, Bauer I, Passalacqua M, Boero S, Donadini A, Millo E, Bellotti M, Sturla L, Damonte P, Puddu A, Ferroni C, Varchi G, Franceschi C, Ballestrero A, Poggi A, Bruzzone S, Nencioni A, Del Rio A. Sociali G, et al. Among authors: boero s. Eur J Med Chem. 2015 Sep 18;102:530-9. doi: 10.1016/j.ejmech.2015.08.024. Epub 2015 Aug 14. Eur J Med Chem. 2015. PMID: 26310895
Nicotinamide phosphoribosyltransferase promotes epithelial-to-mesenchymal transition as a soluble factor independent of its enzymatic activity.
Soncini D, Caffa I, Zoppoli G, Cea M, Cagnetta A, Passalacqua M, Mastracci L, Boero S, Montecucco F, Sociali G, Lasigliè D, Damonte P, Grozio A, Mannino E, Poggi A, D'Agostino VG, Monacelli F, Provenzani A, Odetti P, Ballestrero A, Bruzzone S, Nencioni A. Soncini D, et al. Among authors: boero s. J Biol Chem. 2014 Dec 5;289(49):34189-204. doi: 10.1074/jbc.M114.594721. Epub 2014 Oct 20. J Biol Chem. 2014. PMID: 25331943 Free PMC article.
Sirt6 regulates dendritic cell differentiation, maturation, and function.
Lasigliè D, Boero S, Bauer I, Morando S, Damonte P, Cea M, Monacelli F, Odetti P, Ballestrero A, Uccelli A, Mostoslavsky R, Poggi A, Nencioni A. Lasigliè D, et al. Among authors: boero s. Aging (Albany NY). 2016 Jan;8(1):34-49. doi: 10.18632/aging.100870. Aging (Albany NY). 2016. PMID: 26761436 Free PMC article.
Treatment with KLEPTOSE® CRYSMEB reduces mouse atherogenesis by impacting on lipid profile and Th1 lymphocyte response.
Montecucco F, Lenglet S, Carbone F, Boero S, Pelli G, Burger F, Roth A, Bertolotto M, Nencioni A, Cea M, Dallegri F, Fraga-Silva RA, Fougère L, Elfakir C, Gassner AL, Rudaz S, Parissaux X, Wils D, Salomé M, Vuilleumier N, Poggi A, Mach F. Montecucco F, et al. Among authors: boero s. Vascul Pharmacol. 2015 Sep;72:197-208. doi: 10.1016/j.vph.2015.04.008. Epub 2015 Apr 25. Vascul Pharmacol. 2015. PMID: 25921922
The engagement of CTLA-4 on primary melanoma cell lines induces antibody-dependent cellular cytotoxicity and TNF-α production.
Laurent S, Queirolo P, Boero S, Salvi S, Piccioli P, Boccardo S, Minghelli S, Morabito A, Fontana V, Pietra G, Carrega P, Ferrari N, Tosetti F, Chang LJ, Mingari MC, Ferlazzo G, Poggi A, Pistillo MP. Laurent S, et al. Among authors: boero s. J Transl Med. 2013 May 1;11:108. doi: 10.1186/1479-5876-11-108. J Transl Med. 2013. PMID: 23634660 Free PMC article.
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