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The counterpart congenital overgrowth syndromes Beckwith-Wiedemann Syndrome in human and large offspring syndrome in bovine involve alterations in DNA methylation, transcription, and chromatin configuration.
Li Y, Xiao P, Boadu F, Goldkamp AK, Nirgude S, Cheng J, Hagen DE, Kalish JM, Rivera RM. Li Y, et al. Among authors: boadu f. medRxiv [Preprint]. 2023 Dec 16:2023.12.14.23299981. doi: 10.1101/2023.12.14.23299981. medRxiv. 2023. PMID: 38168424 Free PMC article. Preprint.
Dissection of a Down syndrome-associated trisomy to separate the gene dosage-dependent and -independent effects of an extra chromosome.
Xing Z, Li Y, Cortes-Gomez E, Jiang X, Gao S, Pao A, Shan J, Song Y, Perez A, Yu T, Highsmith MR, Boadu F, Conroy JM, Singh PK, Bakin AV, Cheng J, Duan Z, Wang J, Liu S, Tycko B, Yu YE. Xing Z, et al. Among authors: boadu f. Hum Mol Genet. 2023 Jun 19;32(13):2205-2218. doi: 10.1093/hmg/ddad056. Hum Mol Genet. 2023. PMID: 37014740 Free PMC article.