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Platelet-instructed SPP1+ macrophages drive myofibroblast activation in fibrosis in a CXCL4-dependent manner.
Hoeft K, Schaefer GJL, Kim H, Schumacher D, Bleckwehl T, Long Q, Klinkhammer BM, Peisker F, Koch L, Nagai J, Halder M, Ziegler S, Liehn E, Kuppe C, Kranz J, Menzel S, Costa I, Wahida A, Boor P, Schneider RK, Hayat S, Kramann R. Hoeft K, et al. Among authors: bleckwehl t. Cell Rep. 2023 Feb 28;42(2):112131. doi: 10.1016/j.celrep.2023.112131. Epub 2023 Feb 18. Cell Rep. 2023. PMID: 36807143 Free PMC article.
Dissecting CD8+ T cell pathology of severe SARS-CoV-2 infection by single-cell immunoprofiling.
Schreibing F, Hannani MT, Kim H, Nagai JS, Ticconi F, Fewings E, Bleckwehl T, Begemann M, Torow N, Kuppe C, Kurth I, Kranz J, Frank D, Anslinger TM, Ziegler P, Kraus T, Enczmann J, Balz V, Windhofer F, Balfanz P, Kurts C, Marx G, Marx N, Dreher M, Schneider RK, Saez-Rodriguez J, Costa I, Hayat S, Kramann R. Schreibing F, et al. Among authors: bleckwehl t. Front Immunol. 2022 Dec 16;13:1066176. doi: 10.3389/fimmu.2022.1066176. eCollection 2022. Front Immunol. 2022. PMID: 36591270 Free PMC article.
Enhancer-associated H3K4 methylation safeguards in vitro germline competence.
Bleckwehl T, Crispatzu G, Schaaf K, Respuela P, Bartusel M, Benson L, Clark SJ, Dorighi KM, Barral A, Laugsch M, van IJcken WFJ, Manzanares M, Wysocka J, Reik W, Rada-Iglesias Á. Bleckwehl T, et al. Nat Commun. 2021 Oct 1;12(1):5771. doi: 10.1038/s41467-021-26065-6. Nat Commun. 2021. PMID: 34599190 Free PMC article.
Orphan CpG islands amplify poised enhancer regulatory activity and determine target gene responsiveness.
Pachano T, Sánchez-Gaya V, Ealo T, Mariner-Faulí M, Bleckwehl T, Asenjo HG, Respuela P, Cruz-Molina S, Muñoz-San Martín M, Haro E, van IJcken WFJ, Landeira D, Rada-Iglesias A. Pachano T, et al. Among authors: bleckwehl t. Nat Genet. 2021 Jul;53(7):1036-1049. doi: 10.1038/s41588-021-00888-x. Epub 2021 Jun 28. Nat Genet. 2021. PMID: 34183853 Free PMC article.
Modeling the Pathological Long-Range Regulatory Effects of Human Structural Variation with Patient-Specific hiPSCs.
Laugsch M, Bartusel M, Rehimi R, Alirzayeva H, Karaolidou A, Crispatzu G, Zentis P, Nikolic M, Bleckwehl T, Kolovos P, van Ijcken WFJ, Šarić T, Koehler K, Frommolt P, Lachlan K, Baptista J, Rada-Iglesias A. Laugsch M, et al. Among authors: bleckwehl t. Cell Stem Cell. 2019 May 2;24(5):736-752.e12. doi: 10.1016/j.stem.2019.03.004. Epub 2019 Apr 11. Cell Stem Cell. 2019. PMID: 30982769 Free article.
A paper-based, cell-free biosensor system for the detection of heavy metals and date rape drugs.
Gräwe A, Dreyer A, Vornholt T, Barteczko U, Buchholz L, Drews G, Ho UL, Jackowski ME, Kracht M, Lüders J, Bleckwehl T, Rositzka L, Ruwe M, Wittchen M, Lutter P, Müller K, Kalinowski J. Gräwe A, et al. Among authors: bleckwehl t. PLoS One. 2019 Mar 6;14(3):e0210940. doi: 10.1371/journal.pone.0210940. eCollection 2019. PLoS One. 2019. PMID: 30840628 Free PMC article.
Systematic evaluation of CRISPR-Cas systems reveals design principles for genome editing in human cells.
Wang Y, Liu KI, Sutrisnoh NB, Srinivasan H, Zhang J, Li J, Zhang F, Lalith CRJ, Xing H, Shanmugam R, Foo JN, Yeo HT, Ooi KH, Bleckwehl T, Par YYR, Lee SM, Ismail NNB, Sanwari NAB, Lee STV, Lew J, Tan MH. Wang Y, et al. Among authors: bleckwehl t. Genome Biol. 2018 May 29;19(1):62. doi: 10.1186/s13059-018-1445-x. Genome Biol. 2018. PMID: 29843790 Free PMC article.