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A Neandertal dietary conundrum: Insights provided by tooth enamel Zn isotopes from Gabasa, Spain.
Jaouen K, Villalba-Mouco V, Smith GM, Trost M, Leichliter J, Lüdecke T, Méjean P, Mandrou S, Chmeleff J, Guiserix D, Bourgon N, Blasco F, Mendes Cardoso J, Duquenoy C, Moubtahij Z, Salazar Garcia DC, Richards M, Tütken T, Hublin JJ, Utrilla P, Montes L. Jaouen K, et al. Among authors: blasco f. Proc Natl Acad Sci U S A. 2022 Oct 25;119(43):e2109315119. doi: 10.1073/pnas.2109315119. Epub 2022 Oct 17. Proc Natl Acad Sci U S A. 2022. PMID: 36252021 Free PMC article.
Identification of NVP-CLR457 as an Orally Bioavailable Non-CNS-Penetrant pan-Class IA Phosphoinositol-3-Kinase Inhibitor.
Fairhurst RA, Furet P, Imbach-Weese P, Stauffer F, Rueeger H, McCarthy C, Ripoche S, Oswald S, Arnaud B, Jary A, Maira M, Schnell C, Guthy DA, Wartmann M, Kiffe M, Desrayaud S, Blasco F, Widmer T, Seiler F, Gutmann S, Knapp M, Caravatti G. Fairhurst RA, et al. Among authors: blasco f. J Med Chem. 2022 Jun 23;65(12):8345-8379. doi: 10.1021/acs.jmedchem.2c00267. Epub 2022 May 2. J Med Chem. 2022. PMID: 35500094
NITD-688, a pan-serotype inhibitor of the dengue virus NS4B protein, shows favorable pharmacokinetics and efficacy in preclinical animal models.
Moquin SA, Simon O, Karuna R, Lakshminarayana SB, Yokokawa F, Wang F, Saravanan C, Zhang J, Day CW, Chan K, Wang QY, Lu S, Dong H, Wan KF, Lim SP, Liu W, Seh CC, Chen YL, Xu H, Barkan DT, Kounde CS, Sim WLS, Wang G, Yeo HQ, Zou B, Chan WL, Ding M, Song JG, Li M, Osborne C, Blasco F, Sarko C, Beer D, Bonamy GMC, Sasseville VG, Shi PY, Diagana TT, Yeung BKS, Gu F. Moquin SA, et al. Among authors: blasco f. Sci Transl Med. 2021 Feb 3;13(579):eabb2181. doi: 10.1126/scitranslmed.abb2181. Sci Transl Med. 2021. PMID: 33536278
122 results