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A randomized placebo-controlled clinical trial for pharmacological activation of BCAA catabolism in patients with type 2 diabetes.
Vanweert F, Neinast M, Tapia EE, van de Weijer T, Hoeks J, Schrauwen-Hinderling VB, Blair MC, Bornstein MR, Hesselink MKC, Schrauwen P, Arany Z, Phielix E. Vanweert F, et al. Among authors: blair mc. Nat Commun. 2022 Jun 18;13(1):3508. doi: 10.1038/s41467-022-31249-9. Nat Commun. 2022. PMID: 35717342 Free PMC article. Clinical Trial.
Off-target depletion of plasma tryptophan by allosteric inhibitors of BCKDK.
Bowman CE, Neinast MD, Jang C, Patel J, Blair MC, Mirek ET, Jonsson WO, Chu Q, Merlo L, Mandik-Nayak L, Anthony TG, Rabinowitz JD, Arany Z. Bowman CE, et al. Among authors: blair mc. bioRxiv [Preprint]. 2024 Mar 10:2024.03.05.582974. doi: 10.1101/2024.03.05.582974. bioRxiv. 2024. PMID: 38496495 Free PMC article. Preprint.
Calmodulin inhibitors improve erythropoiesis in Diamond-Blackfan anemia.
Taylor AM, Macari ER, Chan IT, Blair MC, Doulatov S, Vo LT, Raiser DM, Siva K, Basak A, Pirouz M, Shah AN, McGrath K, Humphries JM, Stillman E, Alter BP, Calo E, Gregory RI, Sankaran VG, Flygare J, Ebert BL, Zhou Y, Daley GQ, Zon LI. Taylor AM, et al. Among authors: blair mc. Sci Transl Med. 2020 Oct 21;12(566):eabb5831. doi: 10.1126/scitranslmed.abb5831. Sci Transl Med. 2020. PMID: 33087503 Free PMC article.
Specific oxylipins enhance vertebrate hematopoiesis via the receptor GPR132.
Lahvic JL, Ammerman M, Li P, Blair MC, Stillman ER, Fast EM, Robertson AL, Christodoulou C, Perlin JR, Yang S, Chiang N, Norris PC, Daily ML, Redfield SE, Chan IT, Chatrizeh M, Chase ME, Weis O, Zhou Y, Serhan CN, Zon LI. Lahvic JL, et al. Among authors: blair mc. Proc Natl Acad Sci U S A. 2018 Sep 11;115(37):9252-9257. doi: 10.1073/pnas.1806077115. Epub 2018 Aug 23. Proc Natl Acad Sci U S A. 2018. PMID: 30139917 Free PMC article.