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Arginase 2 Suppresses Renal Carcinoma Progression via Biosynthetic Cofactor Pyridoxal Phosphate Depletion and Increased Polyamine Toxicity.
Ochocki JD, Khare S, Hess M, Ackerman D, Qiu B, Daisak JI, Worth AJ, Lin N, Lee P, Xie H, Li B, Wubbenhorst B, Maguire TG, Nathanson KL, Alwine JC, Blair IA, Nissim I, Keith B, Simon MC. Ochocki JD, et al. Among authors: blair ia. Cell Metab. 2018 Jun 5;27(6):1263-1280.e6. doi: 10.1016/j.cmet.2018.04.009. Epub 2018 May 10. Cell Metab. 2018. PMID: 29754953 Free PMC article.
Cholesterol Auxotrophy as a Targetable Vulnerability in Clear Cell Renal Cell Carcinoma.
Riscal R, Bull CJ, Mesaros C, Finan JM, Carens M, Ho ES, Xu JP, Godfrey J, Brennan P, Johansson M, Purdue MP, Chanock SJ, Mariosa D, Timpson NJ, Vincent EE, Keith B, Blair IA, Skuli N, Simon MC. Riscal R, et al. Among authors: blair ia. Cancer Discov. 2021 Dec 1;11(12):3106-3125. doi: 10.1158/2159-8290.CD-21-0211. Cancer Discov. 2021. PMID: 34244212 Free PMC article.
Bile Acid Metabolism Mediates Cholesterol Homeostasis and Promotes Tumorigenesis in Clear Cell Renal Cell Carcinoma.
Riscal R, Gardner SM, Coffey NJ, Carens M, Mesaros C, Xu JP, Xue Y, Davis L, Demczyszyn S, Vogt A, Olia A, Finan JM, Godfrey J, Schultz DC, Blair IA, Keith B, Marmorstein R, Skuli N, Simon MC. Riscal R, et al. Among authors: blair ia. Cancer Res. 2024 May 15;84(10):1570-1582. doi: 10.1158/0008-5472.CAN-23-0821. Cancer Res. 2024. PMID: 38417134
Akt-dependent metabolic reprogramming regulates tumor cell histone acetylation.
Lee JV, Carrer A, Shah S, Snyder NW, Wei S, Venneti S, Worth AJ, Yuan ZF, Lim HW, Liu S, Jackson E, Aiello NM, Haas NB, Rebbeck TR, Judkins A, Won KJ, Chodosh LA, Garcia BA, Stanger BZ, Feldman MD, Blair IA, Wellen KE. Lee JV, et al. Among authors: blair ia. Cell Metab. 2014 Aug 5;20(2):306-319. doi: 10.1016/j.cmet.2014.06.004. Epub 2014 Jul 3. Cell Metab. 2014. PMID: 24998913 Free PMC article.
ATP-Citrate Lyase Controls a Glucose-to-Acetate Metabolic Switch.
Zhao S, Torres A, Henry RA, Trefely S, Wallace M, Lee JV, Carrer A, Sengupta A, Campbell SL, Kuo YM, Frey AJ, Meurs N, Viola JM, Blair IA, Weljie AM, Metallo CM, Snyder NW, Andrews AJ, Wellen KE. Zhao S, et al. Among authors: blair ia. Cell Rep. 2016 Oct 18;17(4):1037-1052. doi: 10.1016/j.celrep.2016.09.069. Cell Rep. 2016. PMID: 27760311 Free PMC article.
Oncogene-induced Nrf2 transcription promotes ROS detoxification and tumorigenesis.
DeNicola GM, Karreth FA, Humpton TJ, Gopinathan A, Wei C, Frese K, Mangal D, Yu KH, Yeo CJ, Calhoun ES, Scrimieri F, Winter JM, Hruban RH, Iacobuzio-Donahue C, Kern SE, Blair IA, Tuveson DA. DeNicola GM, et al. Among authors: blair ia. Nature. 2011 Jul 6;475(7354):106-9. doi: 10.1038/nature10189. Nature. 2011. PMID: 21734707 Free PMC article.
418 results