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Estrogen receptors and endothelium.
Arnal JF, Fontaine C, Billon-Galés A, Favre J, Laurell H, Lenfant F, Gourdy P. Arnal JF, et al. Among authors: billon gales a. Arterioscler Thromb Vasc Biol. 2010 Aug;30(8):1506-12. doi: 10.1161/ATVBAHA.109.191221. Arterioscler Thromb Vasc Biol. 2010. PMID: 20631350 Review.
The transactivating function 1 of estrogen receptor alpha is dispensable for the vasculoprotective actions of 17beta-estradiol.
Billon-Galés A, Fontaine C, Filipe C, Douin-Echinard V, Fouque MJ, Flouriot G, Gourdy P, Lenfant F, Laurell H, Krust A, Chambon P, Arnal JF. Billon-Galés A, et al. Proc Natl Acad Sci U S A. 2009 Feb 10;106(6):2053-8. doi: 10.1073/pnas.0808742106. Epub 2009 Feb 2. Proc Natl Acad Sci U S A. 2009. PMID: 19188600 Free PMC article.
Endothelial estrogen receptor {alpha} plays an essential role in the coronary and myocardial protective effects of estradiol in ischemia/reperfusion.
Favre J, Gao J, Henry JP, Remy-Jouet I, Fourquaux I, Billon-Gales A, Thuillez C, Arnal JF, Lenfant F, Richard V. Favre J, et al. Among authors: billon gales a. Arterioscler Thromb Vasc Biol. 2010 Dec;30(12):2562-7. doi: 10.1161/ATVBAHA.110.213637. Epub 2010 Sep 16. Arterioscler Thromb Vasc Biol. 2010. PMID: 20847304
Activation function 2 (AF2) of estrogen receptor-alpha is required for the atheroprotective action of estradiol but not to accelerate endothelial healing.
Billon-Galés A, Krust A, Fontaine C, Abot A, Flouriot G, Toutain C, Berges H, Gadeau AP, Lenfant F, Gourdy P, Chambon P, Arnal JF. Billon-Galés A, et al. Proc Natl Acad Sci U S A. 2011 Aug 9;108(32):13311-6. doi: 10.1073/pnas.1105632108. Epub 2011 Jul 25. Proc Natl Acad Sci U S A. 2011. PMID: 21788522 Free PMC article.