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Page 1
Systemic silencing of PHD2 causes reversible immune regulatory dysfunction.
Yamamoto A, Hester J, Macklin PS, Kawai K, Uchiyama M, Biggs D, Bishop T, Bull K, Cheng X, Cawthorne E, Coleman ML, Crockford TL, Davies B, Dow LE, Goldin R, Kranc K, Kudo H, Lawson H, McAuliffe J, Milward K, Scudamore CL, Soilleux E, Issa F, Ratcliffe PJ, Pugh CW. Yamamoto A, et al. Among authors: biggs d. J Clin Invest. 2019 Jun 4;129(9):3640-3656. doi: 10.1172/JCI124099. J Clin Invest. 2019. PMID: 31162141 Free PMC article.
MEF2 transcription factors are key regulators of sprouting angiogenesis.
Sacilotto N, Chouliaras KM, Nikitenko LL, Lu YW, Fritzsche M, Wallace MD, Nornes S, García-Moreno F, Payne S, Bridges E, Liu K, Biggs D, Ratnayaka I, Herbert SP, Molnár Z, Harris AL, Davies B, Bond GL, Bou-Gharios G, Schwarz JJ, De Val S. Sacilotto N, et al. Among authors: biggs d. Genes Dev. 2016 Oct 15;30(20):2297-2309. doi: 10.1101/gad.290619.116. Genes Dev. 2016. PMID: 27898394 Free PMC article.
Single-copy expression of an amyotrophic lateral sclerosis-linked TDP-43 mutation (M337V) in BAC transgenic mice leads to altered stress granule dynamics and progressive motor dysfunction.
Gordon D, Dafinca R, Scaber J, Alegre-Abarrategui J, Farrimond L, Scott C, Biggs D, Kent L, Oliver PL, Davies B, Ansorge O, Wade-Martins R, Talbot K. Gordon D, et al. Among authors: biggs d. Neurobiol Dis. 2019 Jan;121:148-162. doi: 10.1016/j.nbd.2018.09.024. Epub 2018 Oct 2. Neurobiol Dis. 2019. PMID: 30290270 Free article.
An essential cell-autonomous role for hepcidin in cardiac iron homeostasis.
Lakhal-Littleton S, Wolna M, Chung YJ, Christian HC, Heather LC, Brescia M, Ball V, Diaz R, Santos A, Biggs D, Clarke K, Davies B, Robbins PA. Lakhal-Littleton S, et al. Among authors: biggs d. Elife. 2016 Nov 29;5:e19804. doi: 10.7554/eLife.19804. Elife. 2016. PMID: 27897970 Free PMC article.
Cardiac ferroportin regulates cellular iron homeostasis and is important for cardiac function.
Lakhal-Littleton S, Wolna M, Carr CA, Miller JJ, Christian HC, Ball V, Santos A, Diaz R, Biggs D, Stillion R, Holdship P, Larner F, Tyler DJ, Clarke K, Davies B, Robbins PA. Lakhal-Littleton S, et al. Among authors: biggs d. Proc Natl Acad Sci U S A. 2015 Mar 10;112(10):3164-9. doi: 10.1073/pnas.1422373112. Epub 2015 Feb 23. Proc Natl Acad Sci U S A. 2015. PMID: 25713362 Free PMC article.
A versatile transgenic allele for mouse overexpression studies.
Dolatshad H, Biggs D, Diaz R, Hortin N, Preece C, Davies B. Dolatshad H, et al. Among authors: biggs d. Mamm Genome. 2015 Dec;26(11-12):598-608. doi: 10.1007/s00335-015-9602-y. Epub 2015 Sep 14. Mamm Genome. 2015. PMID: 26369329 Free PMC article.
Re-engineering the zinc fingers of PRDM9 reverses hybrid sterility in mice.
Davies B, Hatton E, Altemose N, Hussin JG, Pratto F, Zhang G, Hinch AG, Moralli D, Biggs D, Diaz R, Preece C, Li R, Bitoun E, Brick K, Green CM, Camerini-Otero RD, Myers SR, Donnelly P. Davies B, et al. Among authors: biggs d. Nature. 2016 Feb 11;530(7589):171-176. doi: 10.1038/nature16931. Epub 2016 Feb 3. Nature. 2016. PMID: 26840484 Free PMC article.
235 results