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CIC-39Na reverses the thrombocytopenia that characterizes tubular aggregate myopathy.
Cordero-Sanchez C, Pessolano E, Riva B, Vismara M, Trivigno SMG, Clemente N, Aprile S, Ruffinatti FA, Portararo P, Filigheddu N, Zaggia I, Bhela IP, Serafini M, Pirali T, Colombo MP, Torti M, Sangaletti S, Bertoni A, Genazzani AA. Cordero-Sanchez C, et al. Among authors: bhela ip. Blood Adv. 2022 Aug 9;6(15):4471-4484. doi: 10.1182/bloodadvances.2021006378. Blood Adv. 2022. PMID: 35696753 Free PMC article.
STIM1 and ORAI1 mutations leading to tubular aggregate myopathies are sensitive to the Store-operated Ca2+-entry modulators CIC-37 and CIC-39.
Riva B, Pessolano E, Quaglia E, Cordero-Sanchez C, Bhela IP, Topf A, Serafini M, Cox D, Harris E, Garibaldi M, Barresi R, Pirali T, Genazzani AA. Riva B, et al. Among authors: bhela ip. Cell Calcium. 2022 Jul;105:102605. doi: 10.1016/j.ceca.2022.102605. Epub 2022 May 18. Cell Calcium. 2022. PMID: 35636153 Free article.
An Unexpected Deuterium-Induced Metabolic Switch in Doxophylline.
Aprile S, Colombo G, Serafini M, Di Paola R, Pisati F, Bhela IP, Cuzzocrea S, Grosa G, Pirali T. Aprile S, et al. Among authors: bhela ip. ACS Med Chem Lett. 2022 Jul 14;13(8):1278-1285. doi: 10.1021/acsmedchemlett.2c00166. eCollection 2022 Aug 11. ACS Med Chem Lett. 2022. PMID: 35978700 Free PMC article.
Correction to "An Unexpected Deuterium-Induced Metabolic Switch in Doxophylline".
Aprile S, Colombo G, Serafini M, Di Paola R, Pisati F, Bhela IP, Cuzzocrea S, Grosa G, Pirali T. Aprile S, et al. Among authors: bhela ip. ACS Med Chem Lett. 2023 Nov 27;14(12):1891-1892. doi: 10.1021/acsmedchemlett.3c00497. eCollection 2023 Dec 14. ACS Med Chem Lett. 2023. PMID: 38116440 Free PMC article.