Betz A - Search Results

1

Methotrexate and a spleen tyrosine kinase inhibitor cooperate to inhibit responses to peripheral blood B cells in rheumatoid arthritis.

Coffey G, Betz A, Graf J, Stephens G, Hua Lin P, Imboden J, Sinha U. Coffey G, et al. Among authors: betz a. Pharmacol Res Perspect. 2013 Dec;1(2):e00016. doi: 10.1002/prp2.16. Epub 2013 Dec 15. Pharmacol Res Perspect. 2013. PMID: 25505569 Free PMC article.

2

Specific inhibition of spleen tyrosine kinase suppresses leukocyte immune function and inflammation in animal models of rheumatoid arthritis.

Coffey G, DeGuzman F, Inagaki M, Pak Y, Delaney SM, Ives D, Betz A, Jia ZJ, Pandey A, Baker D, Hollenbach SJ, Phillips DR, Sinha U. Coffey G, et al. Among authors: betz a. J Pharmacol Exp Ther. 2012 Feb;340(2):350-9. doi: 10.1124/jpet.111.188441. Epub 2011 Oct 31. J Pharmacol Exp Ther. 2012. PMID: 22040680

3

The novel kinase inhibitor PRT062070 (Cerdulatinib) demonstrates efficacy in models of autoimmunity and B-cell cancer.

Coffey G, Betz A, DeGuzman F, Pak Y, Inagaki M, Baker DC, Hollenbach SJ, Pandey A, Sinha U. Coffey G, et al. Among authors: betz a. J Pharmacol Exp Ther. 2014 Dec;351(3):538-48. doi: 10.1124/jpet.114.218164. Epub 2014 Sep 24. J Pharmacol Exp Ther. 2014. PMID: 25253883

4

PRT062607 Achieves Complete Inhibition of the Spleen Tyrosine Kinase at Tolerated Exposures Following Oral Dosing in Healthy Volunteers.

Coffey G, Rani A, Betz A, Pak Y, Haberstock-Debic H, Pandey A, Hollenbach S, Gretler DD, Mant T, Jurcevic S, Sinha U. Coffey G, et al. Among authors: betz a. J Clin Pharmacol. 2017 Feb;57(2):194-210. doi: 10.1002/jcph.794. Epub 2016 Aug 17. J Clin Pharmacol. 2017. PMID: 27406873 Free PMC article.

5

Cerdulatinib Pharmacodynamics and Relationships to Tumor Response Following Oral Dosing in Patients with Relapsed/Refractory B-cell Malignancies.

Coffey GP, Feng J, Betz A, Pandey A, Birrell M, Leeds JM, Der K, Kadri S, Lu P, Segal J, Wang YL, Michelson G, Curnutte JT, Conley PB. Coffey GP, et al. Among authors: betz a. Clin Cancer Res. 2019 Feb 15;25(4):1174-1184. doi: 10.1158/1078-0432.CCR-18-1047. Epub 2018 Oct 17. Clin Cancer Res. 2019. PMID: 30333224 Clinical Trial.

6

Differences between human and rabbit coagulation factor X-implications for in vivo models of thrombosis.

Edwards ST, Betz A, James HL, Thompson E, Yonkovich SJ, Sinha U. Edwards ST, et al. Among authors: betz a. Thromb Res. 2002 Apr 1;106(1):71-9. doi: 10.1016/s0049-3848(02)00076-2. Thromb Res. 2002. PMID: 12165292

7

Inhibition of factor Xa by a peptidyl-alpha-ketothiazole involves two steps. Evidence for a stabilizing conformational change.

Betz A, Wong PW, Sinha U. Betz A, et al. Biochemistry. 1999 Nov 2;38(44):14582-91. doi: 10.1021/bi990958a. Biochemistry. 1999. PMID: 10545181

8

Antithrombin binding of low molecular weight heparins and inhibition of factor Xa.

Lin P, Sinha U, Betz A. Lin P, et al. Among authors: betz a. Biochim Biophys Acta. 2001 Apr 3;1526(1):105-13. doi: 10.1016/s0304-4165(01)00117-9. Biochim Biophys Acta. 2001. PMID: 11287128

9

The selective SYK inhibitor P505-15 (PRT062607) inhibits B cell signaling and function in vitro and in vivo and augments the activity of fludarabine in chronic lymphocytic leukemia.

Spurgeon SE, Coffey G, Fletcher LB, Burke R, Tyner JW, Druker BJ, Betz A, DeGuzman F, Pak Y, Baker D, Pandey A, Hollenbach SJ, Sinha U, Loriaux MM. Spurgeon SE, et al. Among authors: betz a. J Pharmacol Exp Ther. 2013 Feb;344(2):378-87. doi: 10.1124/jpet.112.200832. Epub 2012 Dec 7. J Pharmacol Exp Ther. 2013. PMID: 23220742 Free PMC article.

10

Efficacy of the novel selective platelet-derived growth factor receptor antagonist CT52923 on cellular proliferation, migration, and suppression of neointima following vascular injury.

Yu JC, Lokker NA, Hollenbach S, Apatira M, Li J, Betz A, Sedlock D, Oda S, Nomoto Y, Matsuno K, Ide S, Tsukuda E, Giese NA. Yu JC, et al. Among authors: betz a. J Pharmacol Exp Ther. 2001 Sep;298(3):1172-8. J Pharmacol Exp Ther. 2001. PMID: 11504817

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