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Prednisolone reduces the interferon response to AAV in cynomolgus macaques and may increase liver gene expression.
Wang L, Warzecha CC, Kistner A, Chichester JA, Bell P, Buza EL, He Z, Pampena MB, Couthouis J, Sethi S, McKeever K, Betts MR, Kakkis E, Wilson JM, Wadsworth S, Sullivan BA. Wang L, et al. Among authors: betts mr. Mol Ther Methods Clin Dev. 2022 Jan 19;24:292-305. doi: 10.1016/j.omtm.2022.01.007. eCollection 2022 Mar 10. Mol Ther Methods Clin Dev. 2022. PMID: 35211641 Free PMC article.
AAV8 Gene Therapy for Crigler-Najjar Syndrome in Macaques Elicited Transgene T Cell Responses That Are Resident to the Liver.
Greig JA, Calcedo R, Kuri-Cervantes L, Nordin JML, Albrecht J, Bote E, Goode T, Chroscinski EA, Bell P, Richman LK, Betts MR, Wilson JM. Greig JA, et al. Among authors: betts mr. Mol Ther Methods Clin Dev. 2018 Dec 5;11:191-201. doi: 10.1016/j.omtm.2018.10.012. eCollection 2018 Dec 14. Mol Ther Methods Clin Dev. 2018. PMID: 30547050 Free PMC article.
Phenotypic Characterization of SLex+ and CLA+ CD4+ T Cells.
Kuri-Cervantes L, Pampena MB, Betts MR. Kuri-Cervantes L, et al. Among authors: betts mr. STAR Protoc. 2020 Oct 29;1(3):100154. doi: 10.1016/j.xpro.2020.100154. eCollection 2020 Dec 18. STAR Protoc. 2020. PMID: 33377048 Free PMC article.
Immunogenicity of an AAV-based, room-temperature stable, single dose COVID-19 vaccine in mice and non-human primates.
Zabaleta N, Dai W, Bhatt U, Chichester JA, Sanmiguel J, Estelien R, Michalson KT, Diop C, Maciorowski D, Qi W, Hudspeth E, Cucalon A, Dyer CD, Pampena MB, Knox JJ, LaRocque RC, Charles RC, Li D, Kim M, Sheridan A, Storm N, Johnson RI, Feldman J, Hauser BM, Zinn E, Ryan A, Kobayashi DT, Chauhan R, McGlynn M, Ryan ET, Schmidt AG, Price B, Honko A, Griffiths A, Yaghmour S, Hodge R, Betts MR, Freeman MW, Wilson JM, Vandenberghe LH. Zabaleta N, et al. Among authors: betts mr. bioRxiv [Preprint]. 2021 Jan 19:2021.01.05.422952. doi: 10.1101/2021.01.05.422952. bioRxiv. 2021. PMID: 33442684 Free PMC article. Updated. Preprint.
Deep immune profiling of MIS-C demonstrates marked but transient immune activation compared to adult and pediatric COVID-19.
Vella LA, Giles JR, Baxter AE, Oldridge DA, Diorio C, Kuri-Cervantes L, Alanio C, Pampena MB, Wu JE, Chen Z, Huang YJ, Anderson EM, Gouma S, McNerney KO, Chase J, Burudpakdee C, Lee JH, Apostolidis SA, Huang AC, Mathew D, Kuthuru O, Goodwin EC, Weirick ME, Bolton MJ, Arevalo CP, Ramos A, Jasen CJ, Conrey PE, Sayed S, Giannini HM, D'Andrea K; UPenn COVID Processing Unit; Meyer NJ, Behrens EM, Bassiri H, Hensley SE, Henrickson SE, Teachey DT, Betts MR, Wherry EJ. Vella LA, et al. Among authors: betts mr. Sci Immunol. 2021 Mar 2;6(57):eabf7570. doi: 10.1126/sciimmunol.abf7570. Sci Immunol. 2021. PMID: 33653907 Free PMC article.
Erythrocytes identify complement activation in patients with COVID-19.
Lam LKM, Reilly JP, Rux AH, Murphy SJ, Kuri-Cervantes L, Weisman AR, Ittner CAG, Pampena MB, Betts MR, Wherry EJ, Song WC, Lambris JD, Meyer NJ, Cines DB, Mangalmurti NS. Lam LKM, et al. Among authors: betts mr. Am J Physiol Lung Cell Mol Physiol. 2021 Aug 1;321(2):L485-L489. doi: 10.1152/ajplung.00231.2021. Epub 2021 Jul 7. Am J Physiol Lung Cell Mol Physiol. 2021. PMID: 34231390 Free PMC article.
An AAV-based, room-temperature-stable, single-dose COVID-19 vaccine provides durable immunogenicity and protection in non-human primates.
Zabaleta N, Dai W, Bhatt U, Hérate C, Maisonnasse P, Chichester JA, Sanmiguel J, Estelien R, Michalson KT, Diop C, Maciorowski D, Dereuddre-Bosquet N, Cavarelli M, Gallouët AS, Naninck T, Kahlaoui N, Lemaitre J, Qi W, Hudspeth E, Cucalon A, Dyer CD, Pampena MB, Knox JJ, LaRocque RC, Charles RC, Li D, Kim M, Sheridan A, Storm N, Johnson RI, Feldman J, Hauser BM, Contreras V, Marlin R, Tsong Fang RH, Chapon C, van der Werf S, Zinn E, Ryan A, Kobayashi DT, Chauhan R, McGlynn M, Ryan ET, Schmidt AG, Price B, Honko A, Griffiths A, Yaghmour S, Hodge R, Betts MR, Freeman MW, Wilson JM, Le Grand R, Vandenberghe LH. Zabaleta N, et al. Among authors: betts mr. Cell Host Microbe. 2021 Sep 8;29(9):1437-1453.e8. doi: 10.1016/j.chom.2021.08.002. Epub 2021 Aug 7. Cell Host Microbe. 2021. PMID: 34428428 Free PMC article.
187 results