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Exploring natural product chemistry and biology with multicomponent reactions. 5. Discovery of a novel tubulin-targeting scaffold derived from the rigidin family of marine alkaloids.
Frolova LV, Magedov IV, Romero AE, Karki M, Otero I, Hayden K, Evdokimov NM, Banuls LM, Rastogi SK, Smith WR, Lu SL, Kiss R, Shuster CB, Hamel E, Betancourt T, Rogelj S, Kornienko A. Frolova LV, et al. Among authors: betancourt t. J Med Chem. 2013 Sep 12;56(17):6886-900. doi: 10.1021/jm400711t. Epub 2013 Aug 23. J Med Chem. 2013. PMID: 23927793 Free PMC article.
Novel Microtubule-Targeting 7-Deazahypoxanthines Derived from Marine Alkaloid Rigidins with Potent in Vitro and in Vivo Anticancer Activities.
Medellin DC, Zhou Q, Scott R, Hill RM, Frail SK, Dasari R, Ontiveros SJ, Pelly SC, van Otterlo WA, Betancourt T, Shuster CB, Hamel E, Bai R, LaBarbera DV, Rogelj S, Frolova LV, Kornienko A. Medellin DC, et al. Among authors: betancourt t. J Med Chem. 2016 Jan 14;59(1):480-5. doi: 10.1021/acs.jmedchem.5b01426. Epub 2015 Dec 17. J Med Chem. 2016. PMID: 26641132 Free PMC article.
Enhanced Release of Molecules upon Ultraviolet (UV) Light Irradiation from Photoresponsive Hydrogels Prepared from Bifunctional Azobenzene and Four-Arm Poly(ethylene glycol).
Rastogi SK, Anderson HE, Lamas J, Barret S, Cantu T, Zauscher S, Brittain WJ, Betancourt T. Rastogi SK, et al. Among authors: betancourt t. ACS Appl Mater Interfaces. 2018 Sep 12;10(36):30071-30080. doi: 10.1021/acsami.6b16183. Epub 2017 Mar 7. ACS Appl Mater Interfaces. 2018. PMID: 28222261
Microtubule-Targeting 7-Deazahypoxanthines Derived from Marine Alkaloid Rigidins: Exploration of the N3 and N9 Positions and Interaction with Multidrug-Resistance Proteins.
Dasari R, Błauż A, Medellin DC, Kassim RM, Viera C, Santarosa M, van der Westhuyzen AE, van Otterlo WAL, Olivas T, Yildiz T, Betancourt T, Shuster CB, Rogelj S, Rychlik B, Hudnall T, Frolova LV, Kornienko A. Dasari R, et al. Among authors: betancourt t. ChemMedChem. 2019 Feb 5;14(3):322-333. doi: 10.1002/cmdc.201800658. Epub 2019 Jan 25. ChemMedChem. 2019. PMID: 30562414 Free PMC article.
Photo-Uncaging of a Microtubule-Targeted Rigidin Analogue in Hypoxic Cancer Cells and in a Xenograft Mouse Model.
van Rixel VHS, Ramu V, Auyeung AB, Beztsinna N, Leger DY, Lameijer LN, Hilt ST, Le Dévédec SE, Yildiz T, Betancourt T, Gildner MB, Hudnall TW, Sol V, Liagre B, Kornienko A, Bonnet S. van Rixel VHS, et al. Among authors: betancourt t. J Am Chem Soc. 2019 Nov 20;141(46):18444-18454. doi: 10.1021/jacs.9b07225. Epub 2019 Nov 6. J Am Chem Soc. 2019. PMID: 31625740 Free article.
202 results