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Structure-based mechanism of cysteinyl leukotriene receptor inhibition by antiasthmatic drugs.
Luginina A, Gusach A, Marin E, Mishin A, Brouillette R, Popov P, Shiriaeva A, Besserer-Offroy É, Longpré JM, Lyapina E, Ishchenko A, Patel N, Polovinkin V, Safronova N, Bogorodskiy A, Edelweiss E, Hu H, Weierstall U, Liu W, Batyuk A, Gordeliy V, Han GW, Sarret P, Katritch V, Borshchevskiy V, Cherezov V. Luginina A, et al. Sci Adv. 2019 Oct 9;5(10):eaax2518. doi: 10.1126/sciadv.aax2518. eCollection 2019 Oct. Sci Adv. 2019. PMID: 31633023 Free PMC article.
Structural basis of ligand selectivity and disease mutations in cysteinyl leukotriene receptors.
Gusach A, Luginina A, Marin E, Brouillette RL, Besserer-Offroy É, Longpré JM, Ishchenko A, Popov P, Patel N, Fujimoto T, Maruyama T, Stauch B, Ergasheva M, Romanovskaia D, Stepko A, Kovalev K, Shevtsov M, Gordeliy V, Han GW, Katritch V, Borshchevskiy V, Sarret P, Mishin A, Cherezov V. Gusach A, et al. Among authors: besserer offroy e. Nat Commun. 2019 Dec 6;10(1):5573. doi: 10.1038/s41467-019-13348-2. Nat Commun. 2019. PMID: 31811124 Free PMC article.
Structural insights on ligand recognition at the human leukotriene B4 receptor 1.
Michaelian N, Sadybekov A, Besserer-Offroy É, Han GW, Krishnamurthy H, Zamlynny BA, Fradera X, Siliphaivanh P, Presland J, Spencer KB, Soisson SM, Popov P, Sarret P, Katritch V, Cherezov V. Michaelian N, et al. Among authors: besserer offroy e. Nat Commun. 2021 May 20;12(1):2971. doi: 10.1038/s41467-021-23149-1. Nat Commun. 2021. PMID: 34016973 Free PMC article.
In Search of the Optimal Macrocyclization Site for Neurotensin.
Sousbie M, Besserer-Offroy É, Brouillette RL, Longpré JM, Leduc R, Sarret P, Marsault É. Sousbie M, et al. ACS Med Chem Lett. 2018 Jan 29;9(3):227-232. doi: 10.1021/acsmedchemlett.7b00500. eCollection 2018 Mar 8. ACS Med Chem Lett. 2018. PMID: 29541365 Free PMC article.
Use of Molecular Modeling to Design Selective NTS2 Neurotensin Analogues.
Fanelli R, Floquet N, Besserer-Offroy É, Delort B, Vivancos M, Longpré JM, Renault P, Martinez J, Sarret P, Cavelier F. Fanelli R, et al. J Med Chem. 2017 Apr 27;60(8):3303-3313. doi: 10.1021/acs.jmedchem.6b01848. Epub 2017 Apr 10. J Med Chem. 2017. PMID: 28368584
28 results