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Gut vascular barrier impairment leads to intestinal bacteria dissemination and colorectal cancer metastasis to liver.
Bertocchi A, Carloni S, Ravenda PS, Bertalot G, Spadoni I, Lo Cascio A, Gandini S, Lizier M, Braga D, Asnicar F, Segata N, Klaver C, Brescia P, Rossi E, Anselmo A, Guglietta S, Maroli A, Spaggiari P, Tarazona N, Cervantes A, Marsoni S, Lazzari L, Jodice MG, Luise C, Erreni M, Pece S, Di Fiore PP, Viale G, Spinelli A, Pozzi C, Penna G, Rescigno M. Bertocchi A, et al. Cancer Cell. 2021 May 10;39(5):708-724.e11. doi: 10.1016/j.ccell.2021.03.004. Epub 2021 Apr 1. Cancer Cell. 2021. PMID: 33798472 Free article.
A gut-vascular barrier controls the systemic dissemination of bacteria.
Spadoni I, Zagato E, Bertocchi A, Paolinelli R, Hot E, Di Sabatino A, Caprioli F, Bottiglieri L, Oldani A, Viale G, Penna G, Dejana E, Rescigno M. Spadoni I, et al. Among authors: bertocchi a. Science. 2015 Nov 13;350(6262):830-4. doi: 10.1126/science.aad0135. Science. 2015. PMID: 26564856
Identification of a choroid plexus vascular barrier closing during intestinal inflammation.
Carloni S, Bertocchi A, Mancinelli S, Bellini M, Erreni M, Borreca A, Braga D, Giugliano S, Mozzarelli AM, Manganaro D, Fernandez Perez D, Colombo F, Di Sabatino A, Pasini D, Penna G, Matteoli M, Lodato S, Rescigno M. Carloni S, et al. Among authors: bertocchi a. Science. 2021 Oct 22;374(6566):439-448. doi: 10.1126/science.abc6108. Epub 2021 Oct 21. Science. 2021. PMID: 34672740
Endogenous murine microbiota member Faecalibaculum rodentium and its human homologue protect from intestinal tumour growth.
Zagato E, Pozzi C, Bertocchi A, Schioppa T, Saccheri F, Guglietta S, Fosso B, Melocchi L, Nizzoli G, Troisi J, Marzano M, Oresta B, Spadoni I, Atarashi K, Carloni S, Arioli S, Fornasa G, Asnicar F, Segata N, Guglielmetti S, Honda K, Pesole G, Vermi W, Penna G, Rescigno M. Zagato E, et al. Among authors: bertocchi a. Nat Microbiol. 2020 Mar;5(3):511-524. doi: 10.1038/s41564-019-0649-5. Epub 2020 Jan 27. Nat Microbiol. 2020. PMID: 31988379 Free PMC article.
Mucosa-associated microbiota drives pathogenic functions in IBD-derived intestinal iNKT cells.
Burrello C, Pellegrino G, Giuffrè MR, Lovati G, Magagna I, Bertocchi A, Cribiù FM, Boggio F, Botti F, Trombetta E, Porretti L, Di Sabatino A, Vecchi M, Rescigno M, Caprioli F, Facciotti F. Burrello C, et al. Among authors: bertocchi a. Life Sci Alliance. 2019 Feb 13;2(1):e201800229. doi: 10.26508/lsa.201800229. Print 2019 Feb. Life Sci Alliance. 2019. PMID: 30760554 Free PMC article.
Immune microniches shape intestinal Treg function.
Gu Y, Bartolomé-Casado R, Xu C, Bertocchi A, Janney A, Heuberger C, Pearson CF, Teichmann SA, Thornton EE, Powrie F. Gu Y, et al. Among authors: bertocchi a. Nature. 2024 Apr;628(8009):854-862. doi: 10.1038/s41586-024-07251-0. Epub 2024 Apr 3. Nature. 2024. PMID: 38570678 Free PMC article.
IL-3 finds its home in the brain.
Bertocchi A, Dougan SK. Bertocchi A, et al. Immunity. 2023 Jul 11;56(7):1431-1433. doi: 10.1016/j.immuni.2023.06.009. Immunity. 2023. PMID: 37437533
Extrafollicular IgD-CD27-CXCR5-CD11c- DN3 B cells infiltrate inflamed tissues in autoimmune fibrosis and in severe COVID-19.
Allard-Chamard H, Kaneko N, Bertocchi A, Sun N, Boucau J, Kuo HH, Farmer JR, Perugino C, Mahajan VS, Murphy SJH, Premo K, Diefenbach T, Ghebremichael M, Yuen G, Kotta A, Akman Z, Lichterfeld M, Walker BD, Yu XG, Moriyama M, Maehara T, Nakamura S, Stone JH, Padera RF, Pillai S. Allard-Chamard H, et al. Among authors: bertocchi a. Cell Rep. 2023 Jun 27;42(6):112630. doi: 10.1016/j.celrep.2023.112630. Epub 2023 May 30. Cell Rep. 2023. PMID: 37300833 Free PMC article.
MHC class II antigen presentation by intestinal epithelial cells fine-tunes bacteria-reactive CD4 T cell responses.
Heuberger CE, Janney A, Ilott N, Bertocchi A, Pott S, Gu Y, Pohin M, Friedrich M, Mann EH, Pearson C, Powrie FM, Pott J, Thornton E, Maloy KJ. Heuberger CE, et al. Among authors: bertocchi a. Mucosal Immunol. 2023 May 18:S1933-0219(23)00032-6. doi: 10.1016/j.mucimm.2023.05.001. Online ahead of print. Mucosal Immunol. 2023. PMID: 37209960 Free article.
36 results