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Antibiotic class with potent in vivo activity targeting lipopolysaccharide synthesis in Gram-negative bacteria.
Proc Natl Acad Sci U S A. 2024 Apr 9;121(15):e2317274121. doi: 10.1073/pnas.2317274121. Epub 2024 Apr 5.
Proc Natl Acad Sci U S A. 2024.
PMID: 38579010
Free PMC article.
New Dual Inhibitors of Bacterial Topoisomerases with Broad-Spectrum Antibacterial Activity and In Vivo Efficacy against Vancomycin-Intermediate Staphylococcus aureus.
Durcik M, Cotman AE, Toplak Ž, Možina Š, Skok Ž, Szili PE, Czikkely M, Maharramov E, Vu TH, Piras MV, Zidar N, Ilaš J, Zega A, Trontelj J, Pardo LA, Hughes D, Huseby D, Berruga-Fernández T, Cao S, Simoff I, Svensson R, Korol SV, Jin Z, Vicente F, Ramos MC, Mundy JEA, Maxwell A, Stevenson CEM, Lawson DM, Glinghammar B, Sjöström E, Bohlin M, Oreskär J, Alvér S, Janssen GV, Sterk GJ, Kikelj D, Pal C, Tomašič T, Peterlin Mašič L.
Durcik M, et al. Among authors: berruga fernandez t.
J Med Chem. 2023 Mar 23;66(6):3968-3994. doi: 10.1021/acs.jmedchem.2c01905. Epub 2023 Mar 6.
J Med Chem. 2023.
PMID: 36877255
Free PMC article.
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Discovery and Hit-to-Lead Optimization of Benzothiazole Scaffold-Based DNA Gyrase Inhibitors with Potent Activity against Acinetobacter baumannii and Pseudomonas aeruginosa.
Cotman AE, Durcik M, Benedetto Tiz D, Fulgheri F, Secci D, Sterle M, Možina Š, Skok Ž, Zidar N, Zega A, Ilaš J, Peterlin Mašič L, Tomašič T, Hughes D, Huseby DL, Cao S, Garoff L, Berruga Fernández T, Giachou P, Crone L, Simoff I, Svensson R, Birnir B, Korol SV, Jin Z, Vicente F, Ramos MC, de la Cruz M, Glinghammar B, Lenhammar L, Henderson SR, Mundy JEA, Maxwell A, Stevenson CEM, Lawson DM, Janssen GV, Sterk GJ, Kikelj D.
Cotman AE, et al. Among authors: berruga fernandez t.
J Med Chem. 2023 Jan 26;66(2):1380-1425. doi: 10.1021/acs.jmedchem.2c01597. Epub 2023 Jan 12.
J Med Chem. 2023.
PMID: 36634346
Free PMC article.
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Antibacterial activity of apramycin at acidic pH warrants wide therapeutic window in the treatment of complicated urinary tract infections and acute pyelonephritis.
Becker K, Cao S, Nilsson A, Erlandsson M, Hotop SK, Kuka J, Hansen J, Haldimann K, Grinberga S, Berruga-Fernández T, Huseby DL, Shariatgorji R, Lindmark E, Platzack B, Böttger EC, Crich D, Friberg LE, Vingsbo Lundberg C, Hughes D, Brönstrup M, Andrén PE, Liepinsh E, Hobbie SN.
Becker K, et al. Among authors: berruga fernandez t.
EBioMedicine. 2021 Nov;73:103652. doi: 10.1016/j.ebiom.2021.103652. Epub 2021 Nov 2.
EBioMedicine. 2021.
PMID: 34740109
Free PMC article.
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Risk Assessment for the Transmission of Middle East Respiratory Syndrome Coronavirus (MERS-Cov) on Aircraft: A Systematic Review.
Berruga-Fernández T, Robesyn E, Korhonen T, Penttinen P, Jansa JM.
Berruga-Fernández T, et al.
Epidemiol Infect. 2021 Jun 10;149:1-51. doi: 10.1017/S095026882100131X. Online ahead of print.
Epidemiol Infect. 2021.
PMID: 34108058
Free PMC article.
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Sleep Architecture in Night Shift Workers Police Officers with Obstructive Sleep Apnea-hypopnea Syndrome.
Verde-Tinoco S, Santana-Miranda R, Gutiérrez-Escobar R, Haro R, Miranda-Ortiz J, Berruga-Fernandez T, Jimenez-Correa U, Poblano A.
Verde-Tinoco S, et al. Among authors: berruga fernandez t.
Sleep Sci. 2017 Oct-Dec;10(4):136-141. doi: 10.5935/1984-0063.20170024.
Sleep Sci. 2017.
PMID: 29410744
Free PMC article.
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