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Inhibition of the proline metabolism rate-limiting enzyme P5CS allows proliferation of glutamine-restricted cancer cells.
Nat Metab. 2023 Dec;5(12):2131-2147. doi: 10.1038/s42255-023-00919-3. Epub 2023 Nov 13.
Nat Metab. 2023.
PMID: 37957387
SPOP-mutant prostate cancer: Translating fundamental biology into patient care.
Bernasocchi T, Theurillat JP.
Bernasocchi T, et al.
Cancer Lett. 2022 Mar 31;529:11-18. doi: 10.1016/j.canlet.2021.12.024. Epub 2021 Dec 31.
Cancer Lett. 2022.
PMID: 34974131
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Co-occurrence and mutual exclusivity: what cross-cancer mutation patterns can tell us.
El Tekle G, Bernasocchi T, Unni AM, Bertoni F, Rossi D, Rubin MA, Theurillat JP.
El Tekle G, et al. Among authors: bernasocchi t.
Trends Cancer. 2021 Sep;7(9):823-836. doi: 10.1016/j.trecan.2021.04.009. Epub 2021 May 22.
Trends Cancer. 2021.
PMID: 34031014
Review.
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Dual functions of SPOP and ERG dictate androgen therapy responses in prostate cancer.
Bernasocchi T, El Tekle G, Bolis M, Mutti A, Vallerga A, Brandt LP, Spriano F, Svinkina T, Zoma M, Ceserani V, Rinaldi A, Janouskova H, Bossi D, Cavalli M, Mosole S, Geiger R, Dong Z, Yang CG, Albino D, Rinaldi A, Schraml P, Linder S, Carbone GM, Alimonti A, Bertoni F, Moch H, Carr SA, Zwart W, Kruithof-de Julio M, Rubin MA, Udeshi ND, Theurillat JP.
Bernasocchi T, et al.
Nat Commun. 2021 Feb 2;12(1):734. doi: 10.1038/s41467-020-20820-x.
Nat Commun. 2021.
PMID: 33531470
Free PMC article.
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De Novo Variants in SPOP Cause Two Clinically Distinct Neurodevelopmental Disorders.
Nabais Sá MJ, El Tekle G, de Brouwer APM, Sawyer SL, Del Gaudio D, Parker MJ, Kanani F, van den Boogaard MH, van Gassen K, Van Allen MI, Wierenga K, Purcarin G, Elias ER, Begtrup A, Keller-Ramey J, Bernasocchi T, van de Wiel L, Gilissen C, Venselaar H, Pfundt R, Vissers LELM, Theurillat JP, de Vries BBA.
Nabais Sá MJ, et al. Among authors: bernasocchi t.
Am J Hum Genet. 2020 Mar 5;106(3):405-411. doi: 10.1016/j.ajhg.2020.02.001. Epub 2020 Feb 27.
Am J Hum Genet. 2020.
PMID: 32109420
Free PMC article.
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Opposing effects of cancer-type-specific SPOP mutants on BET protein degradation and sensitivity to BET inhibitors.
Janouskova H, El Tekle G, Bellini E, Udeshi ND, Rinaldi A, Ulbricht A, Bernasocchi T, Civenni G, Losa M, Svinkina T, Bielski CM, Kryukov GV, Cascione L, Napoli S, Enchev RI, Mutch DG, Carney ME, Berchuck A, Winterhoff BJN, Broaddus RR, Schraml P, Moch H, Bertoni F, Catapano CV, Peter M, Carr SA, Garraway LA, Wild PJ, Theurillat JP.
Janouskova H, et al. Among authors: bernasocchi t.
Nat Med. 2017 Sep;23(9):1046-1054. doi: 10.1038/nm.4372. Epub 2017 Aug 14.
Nat Med. 2017.
PMID: 28805821
Free PMC article.
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TRIM24 Is an Oncogenic Transcriptional Activator in Prostate Cancer.
Groner AC, Cato L, de Tribolet-Hardy J, Bernasocchi T, Janouskova H, Melchers D, Houtman R, Cato ACB, Tschopp P, Gu L, Corsinotti A, Zhong Q, Fankhauser C, Fritz C, Poyet C, Wagner U, Guo T, Aebersold R, Garraway LA, Wild PJ, Theurillat JP, Brown M.
Groner AC, et al. Among authors: bernasocchi t.
Cancer Cell. 2016 Jun 13;29(6):846-858. doi: 10.1016/j.ccell.2016.04.012. Epub 2016 May 26.
Cancer Cell. 2016.
PMID: 27238081
Free PMC article.
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Interaction of CDCP1 with HER2 enhances HER2-driven tumorigenesis and promotes trastuzumab resistance in breast cancer.
Alajati A, Guccini I, Pinton S, Garcia-Escudero R, Bernasocchi T, Sarti M, Montani E, Rinaldi A, Montemurro F, Catapano C, Bertoni F, Alimonti A.
Alajati A, et al. Among authors: bernasocchi t.
Cell Rep. 2015 Apr 28;11(4):564-76. doi: 10.1016/j.celrep.2015.03.044. Epub 2015 Apr 16.
Cell Rep. 2015.
PMID: 25892239
Free article.
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