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Mimicking Tumor Cell Heterogeneity of Colorectal Cancer in a Patient-derived Organoid-Fibroblast Model.
Atanasova VS, de Jesus Cardona C, Hejret V, Tiefenbacher A, Mair T, Tran L, Pfneissl J, Draganić K, Binder C, Kabiljo J, Clement J, Woeran K, Neudert B, Wohlhaupter S, Haase A, Domazet S, Hengstschläger M, Mitterhauser M, Müllauer L, Tichý B, Bergmann M, Schweikert G, Hartl M, Dolznig H, Egger G. Atanasova VS, et al. Among authors: bergmann m. Cell Mol Gastroenterol Hepatol. 2023;15(6):1391-1419. doi: 10.1016/j.jcmgh.2023.02.014. Epub 2023 Mar 2. Cell Mol Gastroenterol Hepatol. 2023. PMID: 36868311 Free PMC article.
Inactivation of mTORC2 in macrophages is a signature of colorectal cancer that promotes tumorigenesis.
Katholnig K, Schütz B, Fritsch SD, Schörghofer D, Linke M, Sukhbaatar N, Matschinger JM, Unterleuthner D, Hirtl M, Lang M, Herac M, Spittler A, Bergthaler A, Schabbauer G, Bergmann M, Dolznig H, Hengstschläger M, Magnuson MA, Mikula M, Weichhart T. Katholnig K, et al. Among authors: bergmann m. JCI Insight. 2019 Oct 17;4(20):e124164. doi: 10.1172/jci.insight.124164. JCI Insight. 2019. PMID: 31619583 Free PMC article.
Stromal fibroblasts shape the myeloid phenotype in normal colon and colorectal cancer and induce CD163 and CCL2 expression in macrophages.
Stadler M, Pudelko K, Biermeier A, Walterskirchen N, Gaigneaux A, Weindorfer C, Harrer N, Klett H, Hengstschläger M, Schüler J, Sommergruber W, Oehler R, Bergmann M, Letellier E, Dolznig H. Stadler M, et al. Among authors: bergmann m. Cancer Lett. 2021 Nov 1;520:184-200. doi: 10.1016/j.canlet.2021.07.006. Epub 2021 Jul 10. Cancer Lett. 2021. PMID: 34256095 Free article.
Metastatic colorectal carcinoma-associated fibroblasts have immunosuppressive properties related to increased IGFBP2 expression.
Walterskirchen N, Müller C, Ramos C, Zeindl S, Stang S, Herzog D, Sachet M, Schimek V, Unger L, Gerakopoulos V, Hengstschläger M, Bachleitner-Hofmann T, Bergmann M, Dolznig H, Oehler R. Walterskirchen N, et al. Among authors: bergmann m. Cancer Lett. 2022 Aug 1;540:215737. doi: 10.1016/j.canlet.2022.215737. Epub 2022 May 13. Cancer Lett. 2022. PMID: 35569697 Free article.
1,382 results