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Page 1
A kinase-independent role for CDK8 in BCR-ABL1+ leukemia.
Menzl I, Zhang T, Berger-Becvar A, Grausenburger R, Heller G, Prchal-Murphy M, Edlinger L, Knab VM, Uras IZ, Grundschober E, Bauer K, Roth M, Skucha A, Liu Y, Hatcher JM, Liang Y, Kwiatkowski NP, Fux D, Hoelbl-Kovacic A, Kubicek S, Melo JV, Valent P, Weichhart T, Grebien F, Zuber J, Gray NS, Sexl V. Menzl I, et al. Among authors: berger becvar a. Nat Commun. 2019 Oct 18;10(1):4741. doi: 10.1038/s41467-019-12656-x. Nat Commun. 2019. PMID: 31628323 Free PMC article.
Expansion of BCR/ABL1+ cells requires PAK2 but not PAK1.
Edlinger L, Berger-Becvar A, Menzl I, Hoermann G, Greiner G, Grundschober E, Bago-Horvath Z, Al-Zoughbi W, Hoefler G, Brostjan C, Gille L, Moriggl R, Spittler A, Sexl V, Hoelbl-Kovacic A. Edlinger L, et al. Among authors: berger becvar a. Br J Haematol. 2017 Oct;179(2):229-241. doi: 10.1111/bjh.14833. Epub 2017 Jul 14. Br J Haematol. 2017. PMID: 28707321 Free PMC article.
Pharmacologic inhibition of STAT5 in acute myeloid leukemia.
Wingelhofer B, Maurer B, Heyes EC, Cumaraswamy AA, Berger-Becvar A, de Araujo ED, Orlova A, Freund P, Ruge F, Park J, Tin G, Ahmar S, Lardeau CH, Sadovnik I, Bajusz D, Keserű GM, Grebien F, Kubicek S, Valent P, Gunning PT, Moriggl R. Wingelhofer B, et al. Among authors: berger becvar a. Leukemia. 2018 May;32(5):1135-1146. doi: 10.1038/s41375-017-0005-9. Epub 2018 Feb 2. Leukemia. 2018. PMID: 29472718 Free PMC article.
High-throughput thermofluor-based assays for inhibitor screening of STAT SH2 domains.
de Araujo ED, Manaswiyoungkul P, Israelian J, Park J, Yuen K, Farhangi S, Berger-Becvar A, Abu-Jazar L, Gunning PT. de Araujo ED, et al. Among authors: berger becvar a. J Pharm Biomed Anal. 2017 Sep 5;143:159-167. doi: 10.1016/j.jpba.2017.04.052. Epub 2017 May 1. J Pharm Biomed Anal. 2017. PMID: 28600954
ProxyPhos sensors for the detection of negatively charged membranes.
Murcar-Evans BI, Cabral AD, Toutah K, de Araujo ED, Lai A, Macdonald PM, Berger-Becvar A, Kraskouskaya D, Gunning PT. Murcar-Evans BI, et al. Among authors: berger becvar a. Analyst. 2017 Nov 20;142(23):4511-4521. doi: 10.1039/c7an00568g. Analyst. 2017. PMID: 29098228
Identification and Characterization of AES-135, a Hydroxamic Acid-Based HDAC Inhibitor That Prolongs Survival in an Orthotopic Mouse Model of Pancreatic Cancer.
Shouksmith AE, Shah F, Grimard ML, Gawel JM, Raouf YS, Geletu M, Berger-Becvar A, de Araujo ED, Luchman HA, Heaton WL, Bakhshinyan D, Adile AA, Venugopal C, O'Hare T, Deininger MW, Singh SK, Konieczny SF, Weiss S, Fishel ML, Gunning PT. Shouksmith AE, et al. Among authors: berger becvar a. J Med Chem. 2019 Mar 14;62(5):2651-2665. doi: 10.1021/acs.jmedchem.8b01957. Epub 2019 Mar 6. J Med Chem. 2019. PMID: 30776234 Free PMC article.