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Physiological blood-brain transport is impaired with age by a shift in transcytosis.
Yang AC, Stevens MY, Chen MB, Lee DP, Stähli D, Gate D, Contrepois K, Chen W, Iram T, Zhang L, Vest RT, Chaney A, Lehallier B, Olsson N, du Bois H, Hsieh R, Cropper HC, Berdnik D, Li L, Wang EY, Traber GM, Bertozzi CR, Luo J, Snyder MP, Elias JE, Quake SR, James ML, Wyss-Coray T. Yang AC, et al. Among authors: berdnik d. Nature. 2020 Jul;583(7816):425-430. doi: 10.1038/s41586-020-2453-z. Epub 2020 Jul 1. Nature. 2020. PMID: 32612231 Free PMC article.
Undulating changes in human plasma proteome profiles across the lifespan.
Lehallier B, Gate D, Schaum N, Nanasi T, Lee SE, Yousef H, Moran Losada P, Berdnik D, Keller A, Verghese J, Sathyan S, Franceschi C, Milman S, Barzilai N, Wyss-Coray T. Lehallier B, et al. Among authors: berdnik d. Nat Med. 2019 Dec;25(12):1843-1850. doi: 10.1038/s41591-019-0673-2. Epub 2019 Dec 5. Nat Med. 2019. PMID: 31806903 Free PMC article.
Ageing hallmarks exhibit organ-specific temporal signatures.
Schaum N, Lehallier B, Hahn O, Pálovics R, Hosseinzadeh S, Lee SE, Sit R, Lee DP, Losada PM, Zardeneta ME, Fehlmann T, Webber JT, McGeever A, Calcuttawala K, Zhang H, Berdnik D, Mathur V, Tan W, Zee A, Tan M; Tabula Muris Consortium; Pisco AO, Karkanias J, Neff NF, Keller A, Darmanis S, Quake SR, Wyss-Coray T. Schaum N, et al. Among authors: berdnik d. Nature. 2020 Jul;583(7817):596-602. doi: 10.1038/s41586-020-2499-y. Epub 2020 Jul 15. Nature. 2020. PMID: 32669715 Free PMC article.
Molecular hallmarks of heterochronic parabiosis at single-cell resolution.
Pálovics R, Keller A, Schaum N, Tan W, Fehlmann T, Borja M, Kern F, Bonanno L, Calcuttawala K, Webber J, McGeever A; Tabula Muris Consortium; Luo J, Pisco AO, Karkanias J, Neff NF, Darmanis S, Quake SR, Wyss-Coray T. Pálovics R, et al. Nature. 2022 Mar;603(7900):309-314. doi: 10.1038/s41586-022-04461-2. Epub 2022 Mar 2. Nature. 2022. PMID: 35236985 Free PMC article.
APOE ε4 worsens hippocampal CA1 apical neuropil atrophy and episodic memory.
Kerchner GA, Berdnik D, Shen JC, Bernstein JD, Fenesy MC, Deutsch GK, Wyss-Coray T, Rutt BK. Kerchner GA, et al. Among authors: berdnik d. Neurology. 2014 Feb 25;82(8):691-7. doi: 10.1212/WNL.0000000000000154. Epub 2014 Jan 22. Neurology. 2014. PMID: 24453080 Free PMC article.
Human umbilical cord plasma proteins revitalize hippocampal function in aged mice.
Castellano JM, Mosher KI, Abbey RJ, McBride AA, James ML, Berdnik D, Shen JC, Zou B, Xie XS, Tingle M, Hinkson IV, Angst MS, Wyss-Coray T. Castellano JM, et al. Among authors: berdnik d. Nature. 2017 Apr 27;544(7651):488-492. doi: 10.1038/nature22067. Epub 2017 Apr 19. Nature. 2017. PMID: 28424512 Free PMC article.
Single-cell transcriptomics of 20 mouse organs creates a Tabula Muris.
Tabula Muris Consortium; Overall coordination; Logistical coordination; Organ collection and processing; Library preparation and sequencing; Computational data analysis; Cell type annotation; Writing group; Supplemental text writing group; Principal investigators. Tabula Muris Consortium, et al. Nature. 2018 Oct;562(7727):367-372. doi: 10.1038/s41586-018-0590-4. Epub 2018 Oct 3. Nature. 2018. PMID: 30283141 Free PMC article.
32 results