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Discovery of V-0219: A Small-Molecule Positive Allosteric Modulator of the Glucagon-Like Peptide-1 Receptor toward Oral Treatment for "Diabesity".
Decara JM, Vázquez-Villa H, Brea J, Alonso M, Srivastava RK, Orio L, Alén F, Suárez J, Baixeras E, García-Cárceles J, Escobar-Peña A, Lutz B, Rodríguez R, Codesido E, Garcia-Ladona FJ, Bennett TA, Ballesteros JA, Cruces J, Loza MI, Benhamú B, Rodríguez de Fonseca F, López-Rodríguez ML. Decara JM, et al. Among authors: benhamu b. J Med Chem. 2022 Apr 14;65(7):5449-5461. doi: 10.1021/acs.jmedchem.1c01842. Epub 2022 Mar 29. J Med Chem. 2022. PMID: 35349261 Free PMC article.
A Positive Allosteric Modulator of the Serotonin 5-HT2C Receptor for Obesity.
García-Cárceles J, Decara JM, Vázquez-Villa H, Rodríguez R, Codesido E, Cruces J, Brea J, Loza MI, Alén F, Botta J, McCormick PJ, Ballesteros JA, Benhamú B, Rodríguez de Fonseca F, López-Rodríguez ML. García-Cárceles J, et al. Among authors: benhamu b. J Med Chem. 2017 Dec 14;60(23):9575-9584. doi: 10.1021/acs.jmedchem.7b00994. Epub 2017 Nov 17. J Med Chem. 2017. PMID: 29116785
2-(Fluoromethoxy)-4'-(S-methanesulfonimidoyl)-1,1'-biphenyl (UCM-1306), an Orally Bioavailable Positive Allosteric Modulator of the Human Dopamine D1 Receptor for Parkinson's Disease.
García-Cárceles J, Vázquez-Villa H, Brea J, Ladron de Guevara-Miranda D, Cincilla G, Sánchez-Martínez M, Sánchez-Merino A, Algar S, Teresa de Los Frailes M, Roberts RS, Ballesteros JA, Rodríguez de Fonseca F, Benhamú B, Loza MI, López-Rodríguez ML. García-Cárceles J, et al. Among authors: benhamu b. J Med Chem. 2022 Sep 22;65(18):12256-12272. doi: 10.1021/acs.jmedchem.2c00949. Epub 2022 Aug 31. J Med Chem. 2022. PMID: 36044544 Free PMC article.
Development of molecular probes for the human 5-HT(6) receptor.
Vázquez-Villa H, González-Vera JA, Benhamú B, Viso A, Fernández de la Pradilla R, Junquera E, Aicart E, López-Rodríguez ML, Ortega-Gutiérrez S. Vázquez-Villa H, et al. Among authors: benhamu b. J Med Chem. 2010 Oct 14;53(19):7095-106. doi: 10.1021/jm1007177. J Med Chem. 2010. PMID: 20845907
Development of non-peptide ligands of growth factor receptor-bound protein 2-SRC homology 2 domain using molecular modeling and NMR spectroscopy.
Orcajo-Rincón ÁL, Ortega-Gutiérrez S, Serrano P, Torrecillas IR, Wüthrich K, Campillo M, Pardo L, Viso A, Benhamú B, López-Rodríguez ML. Orcajo-Rincón ÁL, et al. Among authors: benhamu b. J Med Chem. 2011 Feb 24;54(4):1096-100. doi: 10.1021/jm101478n. Epub 2011 Jan 27. J Med Chem. 2011. PMID: 21271718
New synthetic inhibitors of fatty acid synthase with anticancer activity.
Turrado C, Puig T, García-Cárceles J, Artola M, Benhamú B, Ortega-Gutiérrez S, Relat J, Oliveras G, Blancafort A, Haro D, Marrero PF, Colomer R, López-Rodríguez ML. Turrado C, et al. Among authors: benhamu b. J Med Chem. 2012 Jun 14;55(11):5013-23. doi: 10.1021/jm2016045. Epub 2012 May 16. J Med Chem. 2012. PMID: 22559865
45 results