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Synthesis and characterization of novel oxazines and demonstration that they specifically target cyclooxygenase 2.
Srinivas V, Mohan CD, Baburajeev CP, Rangappa S, Jagadish S, Fuchs JE, Sukhorukov AY, Chandra, Mason DJ, Sharath Kumar KS, Madegowda M, Bender A, Basappa, Rangappa KS. Srinivas V, et al. Among authors: bender a. Bioorg Med Chem Lett. 2015 Aug 1;25(15):2931-6. doi: 10.1016/j.bmcl.2015.05.047. Epub 2015 May 27. Bioorg Med Chem Lett. 2015. PMID: 26048794
Connecting gene expression data from connectivity map and in silico target predictions for small molecule mechanism-of-action analysis.
Ravindranath AC, Perualila-Tan N, Kasim A, Drakakis G, Liggi S, Brewerton SC, Mason D, Bodkin MJ, Evans DA, Bhagwat A, Talloen W, Göhlmann HW, Shkedy Z, Bender A; QSTAR Consortium. Ravindranath AC, et al. Among authors: bender a. Mol Biosyst. 2015 Jan;11(1):86-96. doi: 10.1039/c4mb00328d. Epub 2014 Sep 25. Mol Biosyst. 2015. PMID: 25254964
Development of a novel azaspirane that targets the Janus kinase-signal transducer and activator of transcription (STAT) pathway in hepatocellular carcinoma in vitro and in vivo.
Mohan CD, Bharathkumar H, Bulusu KC, Pandey V, Rangappa S, Fuchs JE, Shanmugam MK, Dai X, Li F, Deivasigamani A, Hui KM, Kumar AP, Lobie PE, Bender A, Basappa, Sethi G, Rangappa KS. Mohan CD, et al. Among authors: bender a. J Biol Chem. 2014 Dec 5;289(49):34296-307. doi: 10.1074/jbc.M114.601104. Epub 2014 Oct 15. J Biol Chem. 2014. PMID: 25320076 Free PMC article.
Novel synthetic coumarins that targets NF-κB in Hepatocellular carcinoma.
Neelgundmath M, Dinesh KR, Mohan CD, Li F, Dai X, Siveen KS, Paricharak S, Mason DJ, Fuchs JE, Sethi G, Bender A, Rangappa KS, Kotresh O, Basappa. Neelgundmath M, et al. Among authors: bender a. Bioorg Med Chem Lett. 2015 Feb 15;25(4):893-7. doi: 10.1016/j.bmcl.2014.12.065. Epub 2014 Dec 30. Bioorg Med Chem Lett. 2015. PMID: 25592709
Microwave-assisted synthesis, characterization and cytotoxic studies of novel estrogen receptor α ligands towards human breast cancer cells.
Bharathkumar H, Mohan CD, Ananda H, Fuchs JE, Li F, Rangappa S, Surender M, Bulusu KC, Girish KS, Sethi G, Bender A, Basappa, Rangappa KS. Bharathkumar H, et al. Among authors: bender a. Bioorg Med Chem Lett. 2015 Apr 15;25(8):1804-1807. doi: 10.1016/j.bmcl.2015.01.030. Epub 2015 Feb 7. Bioorg Med Chem Lett. 2015. PMID: 25797502
Screening of quinoline, 1,3-benzoxazine, and 1,3-oxazine-based small molecules against isolated methionyl-tRNA synthetase and A549 and HCT116 cancer cells including an in silico binding mode analysis.
Bharathkumar H, Mohan CD, Rangappa S, Kang T, Keerthy HK, Fuchs JE, Kwon NH, Bender A, Kim S, Basappa, Rangappa KS. Bharathkumar H, et al. Among authors: bender a. Org Biomol Chem. 2015 Sep 28;13(36):9381-7. doi: 10.1039/c5ob00791g. Epub 2015 Jul 10. Org Biomol Chem. 2015. PMID: 26159576
1,307 results