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Hypoxia decreases insulin signaling pathways in adipocytes.
Regazzetti C, Peraldi P, Grémeaux T, Najem-Lendom R, Ben-Sahra I, Cormont M, Bost F, Le Marchand-Brustel Y, Tanti JF, Giorgetti-Peraldi S. Regazzetti C, et al. Diabetes. 2009 Jan;58(1):95-103. doi: 10.2337/db08-0457. Epub 2008 Nov 4. Diabetes. 2009. PMID: 18984735 Free PMC article.
Targeting cancer cell metabolism: the combination of metformin and 2-deoxyglucose induces p53-dependent apoptosis in prostate cancer cells.
Ben Sahra I, Laurent K, Giuliano S, Larbret F, Ponzio G, Gounon P, Le Marchand-Brustel Y, Giorgetti-Peraldi S, Cormont M, Bertolotto C, Deckert M, Auberger P, Tanti JF, Bost F. Ben Sahra I, et al. Cancer Res. 2010 Mar 15;70(6):2465-75. doi: 10.1158/0008-5472.CAN-09-2782. Epub 2010 Mar 9. Cancer Res. 2010. PMID: 20215500
The energy disruptor metformin targets mitochondrial integrity via modification of calcium flux in cancer cells.
Loubiere C, Clavel S, Gilleron J, Harisseh R, Fauconnier J, Ben-Sahra I, Kaminski L, Laurent K, Herkenne S, Lacas-Gervais S, Ambrosetti D, Alcor D, Rocchi S, Cormont M, Michiels JF, Mari B, Mazure NM, Scorrano L, Lacampagne A, Gharib A, Tanti JF, Bost F. Loubiere C, et al. Sci Rep. 2017 Jul 11;7(1):5040. doi: 10.1038/s41598-017-05052-2. Sci Rep. 2017. PMID: 28698627 Free PMC article.
PGC1α Inhibits Polyamine Synthesis to Suppress Prostate Cancer Aggressiveness.
Kaminski L, Torrino S, Dufies M, Djabari Z, Haider R, Roustan FR, Jaune E, Laurent K, Nottet N, Michiels JF, Gesson M, Rocchi S, Mazure NM, Durand M, Tanti JF, Ambrosetti D, Clavel S, Ben-Sahra I, Bost F. Kaminski L, et al. Cancer Res. 2019 Jul 1;79(13):3268-3280. doi: 10.1158/0008-5472.CAN-18-2043. Epub 2019 May 7. Cancer Res. 2019. PMID: 31064849 Free PMC article.
67 results