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Highly chiral muscarinic ligands: the discovery of (2S,2'R,3'S,5'R)-1-methyl-2-(2-methyl-1,3-oxathiolan-5-yl)pyrrolidine 3-sulfoxide methyl iodide, a potent, functionally selective, M2 partial agonist.
Scapecchi S, Matucci R, Bellucci C, Buccioni M, Dei S, Guandalini L, Martelli C, Manetti D, Martini E, Marucci G, Nesi M, Romanelli MN, Teodori E, Gualtieri F. Scapecchi S, et al. Among authors: bellucci c. J Med Chem. 2006 Mar 23;49(6):1925-31. doi: 10.1021/jm0510878. J Med Chem. 2006. PMID: 16539379
Synthesis, affinity profile, and functional activity of muscarinic antagonists with a 1-methyl-2-(2,2-alkylaryl-1,3-oxathiolan-5-yl)pyrrolidine structure.
Dei S, Bellucci C, Buccioni M, Ferraroni M, Guandalini L, Manetti D, Martini E, Marucci G, Matucci R, Nesi M, Romanelli MN, Scapecchi S, Teodori E. Dei S, et al. Among authors: bellucci c. J Med Chem. 2007 Mar 22;50(6):1409-13. doi: 10.1021/jm061374r. Epub 2007 Feb 17. J Med Chem. 2007. PMID: 17305327
Synthesis and pharmacological characterization of chiral pyrrolidinylfuran derivatives: the discovery of new functionally selective muscarinic agonists.
Scapecchi S, Nesi M, Matucci R, Bellucci C, Buccioni M, Dei S, Guandalini L, Manetti D, Martini E, Marucci G, Romanelli MN, Teodori E, Cirilli R. Scapecchi S, et al. Among authors: bellucci c. J Med Chem. 2008 Jul 10;51(13):3905-12. doi: 10.1021/jm800145d. Epub 2008 Jun 11. J Med Chem. 2008. PMID: 18543900
New structure-activity relationship studies in a series of N,N-bis(cyclohexanol)amine aryl esters as potent reversers of P-glycoprotein-mediated multidrug resistance (MDR).
Orlandi F, Coronnello M, Bellucci C, Dei S, Guandalini L, Manetti D, Martelli C, Romanelli MN, Scapecchi S, Salerno M, Menif H, Bello I, Mini E, Teodori E. Orlandi F, et al. Among authors: bellucci c. Bioorg Med Chem. 2013 Jan 15;21(2):456-65. doi: 10.1016/j.bmc.2012.11.019. Epub 2012 Nov 24. Bioorg Med Chem. 2013. PMID: 23245571
New quinoline derivatives as nicotinic receptor modulators.
Manetti D, Bellucci C, Dei S, Teodori E, Varani K, Spirova E, Kudryavtsev D, Shelukhina I, Tsetlin V, Romanelli MN. Manetti D, et al. Among authors: bellucci c. Eur J Med Chem. 2016 Mar 3;110:246-58. doi: 10.1016/j.ejmech.2016.01.025. Epub 2016 Jan 19. Eur J Med Chem. 2016. PMID: 26840365
New Rigid Nicotine Analogues, Carrying a Norbornane Moiety, Are Potent Agonists of α7 and α3* Nicotinic Receptors.
Manetti D, Garifulina A, Bartolucci G, Bazzicalupi C, Bellucci C, Chiaramonte N, Dei S, Di Cesare Mannelli L, Ghelardini C, Gratteri P, Spirova E, Shelukhina I, Teodori E, Varani K, Tsetlin V, Romanelli MN. Manetti D, et al. Among authors: bellucci c. J Med Chem. 2019 Feb 28;62(4):1887-1901. doi: 10.1021/acs.jmedchem.8b01372. Epub 2019 Feb 8. J Med Chem. 2019. PMID: 30681854
162 results