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The DUX4 gene at the FSHD1A locus encodes a pro-apoptotic protein.
Kowaljow V, Marcowycz A, Ansseau E, Conde CB, Sauvage S, Mattéotti C, Arias C, Corona ED, Nuñez NG, Leo O, Wattiez R, Figlewicz D, Laoudj-Chenivesse D, Belayew A, Coppée F, Rosa AL. Kowaljow V, et al. Among authors: belayew a. Neuromuscul Disord. 2007 Aug;17(8):611-23. doi: 10.1016/j.nmd.2007.04.002. Epub 2007 Jun 27. Neuromuscul Disord. 2007. PMID: 17588759
DUX4, a candidate gene of facioscapulohumeral muscular dystrophy, encodes a transcriptional activator of PITX1.
Dixit M, Ansseau E, Tassin A, Winokur S, Shi R, Qian H, Sauvage S, Mattéotti C, van Acker AM, Leo O, Figlewicz D, Barro M, Laoudj-Chenivesse D, Belayew A, Coppée F, Chen YW. Dixit M, et al. Among authors: belayew a. Proc Natl Acad Sci U S A. 2007 Nov 13;104(46):18157-62. doi: 10.1073/pnas.0708659104. Epub 2007 Nov 5. Proc Natl Acad Sci U S A. 2007. PMID: 17984056 Free PMC article.
DUX4c is up-regulated in FSHD. It induces the MYF5 protein and human myoblast proliferation.
Ansseau E, Laoudj-Chenivesse D, Marcowycz A, Tassin A, Vanderplanck C, Sauvage S, Barro M, Mahieu I, Leroy A, Leclercq I, Mainfroid V, Figlewicz D, Mouly V, Butler-Browne G, Belayew A, Coppée F. Ansseau E, et al. Among authors: belayew a. PLoS One. 2009 Oct 15;4(10):e7482. doi: 10.1371/journal.pone.0007482. PLoS One. 2009. PMID: 19829708 Free PMC article.
The Krüppel-like factor 15 as a molecular link between myogenic factors and a chromosome 4q transcriptional enhancer implicated in facioscapulohumeral dystrophy.
Dmitriev P, Petrov A, Ansseau E, Stankevicins L, Charron S, Kim E, Bos TJ, Robert T, Turki A, Coppée F, Belayew A, Lazar V, Carnac G, Laoudj D, Lipinski M, Vassetzky YS. Dmitriev P, et al. Among authors: belayew a. J Biol Chem. 2011 Dec 30;286(52):44620-31. doi: 10.1074/jbc.M111.254052. Epub 2011 Sep 21. J Biol Chem. 2011. PMID: 21937448 Free PMC article.
101 results