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DCAF1-based PROTACs with activity against clinically validated targets overcoming intrinsic- and acquired-degrader resistance.
Schröder M, Renatus M, Liang X, Meili F, Zoller T, Ferrand S, Gauter F, Li X, Sigoillot F, Gleim S, Stachyra TM, Thomas JR, Begue D, Khoshouei M, Lefeuvre P, Andraos-Rey R, Chung B, Ma R, Pinch B, Hofmann A, Schirle M, Schmiedeberg N, Imbach P, Gorses D, Calkins K, Bauer-Probst B, Maschlej M, Niederst M, Maher R, Henault M, Alford J, Ahrne E, Tordella L, Hollingworth G, Thomä NH, Vulpetti A, Radimerski T, Holzer P, Carbonneau S, Thoma CR. Schröder M, et al. Among authors: begue d. Nat Commun. 2024 Jan 4;15(1):275. doi: 10.1038/s41467-023-44237-4. Nat Commun. 2024. PMID: 38177131 Free PMC article.
Therapeutic Assessment of Targeting ASNS Combined with l-Asparaginase Treatment in Solid Tumors and Investigation of Resistance Mechanisms.
Apfel V, Begue D, Cordo' V, Holzer L, Martinuzzi L, Buhles A, Kerr G, Barbosa I, Naumann U, Piquet M, Ruddy D, Weiss A, Ferretti S, Almeida R, Bonenfant D, Tordella L, Galli GG. Apfel V, et al. Among authors: begue d. ACS Pharmacol Transl Sci. 2021 Jan 13;4(1):327-337. doi: 10.1021/acsptsci.0c00196. eCollection 2021 Feb 12. ACS Pharmacol Transl Sci. 2021. PMID: 33615182 Free PMC article.
TMEM41B is a novel regulator of autophagy and lipid mobilization.
Moretti F, Bergman P, Dodgson S, Marcellin D, Claerr I, Goodwin JM, DeJesus R, Kang Z, Antczak C, Begue D, Bonenfant D, Graff A, Genoud C, Reece-Hoyes JS, Russ C, Yang Z, Hoffman GR, Mueller M, Murphy LO, Xavier RJ, Nyfeler B. Moretti F, et al. Among authors: begue d. EMBO Rep. 2018 Sep;19(9):e45889. doi: 10.15252/embr.201845889. Epub 2018 Aug 20. EMBO Rep. 2018. PMID: 30126924 Free PMC article.
Haddon's POAV2 vs POAV theory for non-planar molecules.
Sabalot-Cuzzubbo J, Cresson N, Salvato Vallverdu G, Bégué D, Cresson J. Sabalot-Cuzzubbo J, et al. Among authors: begue d. J Chem Phys. 2023 Nov 7;159(17):174109. doi: 10.1063/5.0170800. J Chem Phys. 2023. PMID: 37933779
Influence of solvents on the morphology of Langmuir and Langmuir-Schaefer films of PCBM and PCBM-based oligomers and polymers.
Roncaselli LKM, Silva EA, Braunger ML, Ramanitra HH, Stephen M, Citolino LVL, Fernandes JD, Simõis AVS, Constantino CJL, Agostini DLS, Bégué D, Hiorns RC, Olivati CA. Roncaselli LKM, et al. Among authors: begue d. Phys Chem Chem Phys. 2022 May 25;24(20):12442-12456. doi: 10.1039/d1cp05408b. Phys Chem Chem Phys. 2022. PMID: 35575028
76 results